Draft:Childhood dementia
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Last edited by Irina Rainbow (talk | contribs) 7 hours ago. (Update) |
| Childhood dementia | |
|---|---|
| Symptoms | Loss of previously acquired developmental skills |
Childhood dementia is an umbrella group[1][2] of over 100[1][3][4] rare neurodegenerative conditions[1][5][4] that start to show symptoms in childhood or adolescence.[1][6][7] It's estimated that just 25 to 29% of those affected reach adulthood, and only 10% reach 50.
Childhood dementia conditions cause progressive neurocognitive decline, which develops into a loss of previously learned developmental skills, such as the ability to walk, talk, read/write, among others.
Prognosis
[edit]The conditions within this group cause a progressive decline of neurocognitive function[1][3][5], causing the loss of previously learned developmental skills[1][5][8]. This neurocognitive decline severely reduces both the life expectancy and quality of life of the people it affects.[1][8]
In the later stages of childhood dementia conditions, the brain can progressively lose the ability to keep the body functioning, eventually resulting in that person's death.[6][7][8]
Life expectancy
[edit]Among those born with an untreatable childhood dementia condition, it's estimated only 25[8]-29%[1] survive to an age of 18, and only 10% reach an age of 50.[1]
For this group, the median life expectancy is estimated as around 9 years, whereas the mean life expectancy has been calculated to be 16.3 years.[1]
Quality of life
[edit]While in most cases, people affected initially develop without noticeable problems[3][4], they begin to progressively lose previously acquired developmental skills[1][3], such as the abilities to write, read, talk, walk, play[6], learn, remember, or reason.[3] Over the course of the disease, affected individuals become increasingly dependent on care, and eventually bedridden.[4] In addition, people affected can have a range of complications depending on the subtype, with significant impacts on quality of life.[1]
Causes
[edit]Diagnosis
[edit]Prevention
[edit]Management
[edit]For the non-treatable conditions encompassed by childhood dementia, the focus is on managing symptoms.[1] This can include the use of:
- anti-seizure and behaviour modifying medications[1]
- sleep-aids to treat insomnia[1]
- muscle relaxants to treat muscle stiffness[1]
And therapies like physiotherapy, occupational therapy, speech therapy[1]
Signs and Symptoms
[edit]Psychiatric
[edit]- hiperactivity[3][7]
- trouble concentrating, learning, communicating, or understanding[7]
- confusion[7]
- agression[3]
- amnesia[7]
- personality changes[7]
Potential complications
[edit]- Loss of vision or hearing[3][7]
- Seizures[8][4][7]
- Complete loss of motor skills / movement[4][7]
- Cardiovascular[1][8][7], respiratory[1][8][7], or digestive problems[1][7]
- Bone or joint problems[1][7]
Epidemiology
[edit]History
[edit]Society and culture
[edit]References
[edit]- ^ a b c d e f g h i j k l m n o p q r s t u Elvidge, Kristina L; Christodoulou, John; Farrar, Michelle A; Tilden, Dominic; Maack, Megan; Valeri, Madeline; Ellis, Magda; Smith, Nicholas J C (20 July 2023). "collective burden of childhood dementia: a scoping review | Brain | Oxford Academic". Oxford Academic. Retrieved 2024-09-04.
- ^ "Childhood Dementia Support | Dementia Support Australia". www.dementia.com.au. Retrieved 2024-09-18.
- ^ a b c d e f g h Hemsley, Kim; Smith, Nicholas; Mubarokah, Siti (2024-04-26). "What is childhood dementia? And how could new research help?". The Conversation. Retrieved 2024-09-19.
- ^ a b c d e f Oeffentlichkeitsarbeit, DZNE Abt fuer Presse-und. "Childhood dementia". DZNE (in German). Retrieved 2024-09-13.
- ^ a b c Djafar, Jason V.; Johnson, Alexandra M.; Elvidge, Kristina L.; Farrar, Michelle A. (2023-02-01). "Childhood Dementia: A Collective Clinical Approach to Advance Therapeutic Development and Care". Pediatric Neurology. 139: 76–85. doi:10.1016/j.pediatrneurol.2022.11.015. ISSN 0887-8994. PMID 36571866.
- ^ a b c "What is Childhood Dementia?". childhooddementia.org. Retrieved 2024-09-04.
- ^ a b c d e f g h i j k l m n "Childhood dementia | Dementia Australia". www.dementia.org.au. Retrieved 2024-09-13.
- ^ a b c d e f g Nevin, Suzanne M.; McGill, Brittany C.; Kelada, Lauren; Hilton, Gail; Maack, Megan; Elvidge, Kristina L.; Farrar, Michelle A.; Baynam, Gareth; Katz, Naomi T.; Donovan, Leigh; Grattan, Sarah; Signorelli, Christina; Bhattacharya, Kaustuv; Nunn, Kenneth; Wakefield, Claire E. (2023-09-07). "The psychosocial impact of childhood dementia on children and their parents: a systematic review". Orphanet Journal of Rare Diseases. 18 (1): 277. doi:10.1186/s13023-023-02859-3. ISSN 1750-1172. PMC 10486052. PMID 37679855.