Jump to content

Colchicine

From Wikipedia, the free encyclopedia
(Redirected from Colchicines)

Colchicine
Skeletal formula of colchicine
Ball-and-stick model of the colchicine molecule
Clinical data
Pronunciation/ˈkɒltʃɪsiːn/ KOL-chiss-een
Trade namesColcrys, Mitigare, others
AHFS/Drugs.comMonograph
MedlinePlusa682711
License data
Pregnancy
category
  • AU: D
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability45%
Protein binding35-44%
MetabolismMetabolism, partly by CYP3A4
Elimination half-life26.6-31.2 hours
ExcretionFeces (65%)
Identifiers
  • N-[(7S)-1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.000.544 Edit this at Wikidata
Chemical and physical data
FormulaC22H25NO6
Molar mass399.443 g·mol−1
3D model (JSmol)
  • CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC
  • InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1 checkY
  • Key:IAKHMKGGTNLKSZ-INIZCTEOSA-N checkY
  (verify)

Colchicine is a medication used to prevent and treat gout,[3][4] to treat familial Mediterranean fever[5] and Behçet's disease,[6] and to reduce the risk of myocardial infarction.[7] The American College of Rheumatology recommends colchicine, nonsteroidal anti-inflammatory drugs (NSAIDs) or steroids in the treatment of gout.[8][9] Other uses for colchicine include the management of pericarditis.[10]

Colchicine is taken by mouth.[11] The injectable route of administration for colchicine can be lethal. In 2008, the FDA removed all injectable colchicine from the US market.[12]

Colchicine has a narrow therapeutic index, so overdosing is a significant risk. Common side effects of colchicine include gastrointestinal upset, particularly at high doses.[13] Severe side effects may include pancytopenia (low blood cell counts) and rhabdomyolysis (damage to skeletal muscle), and the medication can be deadly in overdose.[11] Whether colchicine is safe for use during pregnancy is unclear, but its use during breastfeeding appears to be safe.[11][14] Colchicine works by decreasing inflammation via multiple mechanisms.[15]

Colchicine, in the form of the autumn crocus (Colchicum autumnale), was used as early as 1500 BC to treat joint swelling.[16] It was approved for medical use in the United States in 1961.[2] It is available as a generic medication.[14] In 2022, it was the 197th most commonly prescribed medication in the United States, with more than 2 million prescriptions.[17][18]

Colchicine is used in plant breeding to induce polyploidy, in which the number of chromosomes in plant cells are doubled. This helps produce larger, hardier, faster-growing, and in general, more desirable plants than the normally diploid parents.[19]

Medical uses

[edit]

Gout

[edit]

Colchicine is an alternative for those unable to tolerate NSAIDs when treating gout.[20][21][22][23] Low doses (1.2 mg in one hour, followed by 0.6 mg an hour later) appear to be well tolerated and may reduce gout symptoms and pain, perhaps as effectively as NSAIDs.[24] At higher doses, side effects (primarily diarrhea, nausea, or vomiting) limit its use.[24]

For treating gout symptoms, colchicine is taken orally, with or without food, as symptoms first appear.[25] Subsequent doses may be needed if symptoms worsen.[25]

There is preliminary evidence that daily colchicine (0.6 mg twice daily) may be effective as a long-term prophylaxis when used with allopurinol to reduce the risk of increased uric acid levels and acute gout flares;[26] adverse gastrointestinal effects may occur,[27] though overall the risk of serious side effects is low.[28][29]

Risk of cardiovascular disorders

[edit]

In June 2023, the U.S. FDA approved a low-dose regimen of colchicine (tradename LODOCO)[30] to reduce the risk of further disorders in adults with existing cardiovascular diseases.[31][32] As an anti-inflammatory drug, Lodoco in a dose of 0.5 mg per day reduced the rate of cardiovascular events by 31% in people with established atherosclerosis and by 23% in people with recent myocardial infarction.[32] Colchicine was most effective in combination therapy with lipid-lowering and anti-inflammatory medications.[32] The mechanism for this effect of colchicine is unknown.[31]

Other conditions

[edit]

Colchicine is also used as an anti-inflammatory agent for long-term treatment of Behçet's disease.[33] It appears to have limited effect in relapsing polychondritis, as it may only be useful for the treatment of chondritis and mild skin symptoms.[34] It is a component of therapy for several other conditions, including pericarditis, pulmonary fibrosis, biliary cirrhosis, various vasculitides, pseudogout, spondyloarthropathy, calcinosis, scleroderma, and amyloidosis.[33][35][36] Research regarding the efficacy of colchicine in many of these diseases has not been performed.[36] It is also used in the treatment of familial Mediterranean fever,[33] in which it reduces attacks and the long-term risk of amyloidosis.[37]

Colchicine is effective for prevention of atrial fibrillation after cardiac surgery.[38] In people with recent myocardial infarction (recent heart attack), it has been found to reduce risk of future cardiovascular events. Its clinical use may grow to include this indication.[39][40]

Contraindications

[edit]

Long-term (prophylactic) regimens of oral colchicine are absolutely contraindicated in people with advanced kidney failure (including those on dialysis).[25] About 10–20% of a colchicine dose is excreted unchanged by the kidneys; it is not removed by hemodialysis. Cumulative toxicity is a high probability in this clinical setting, and a severe neuromyopathy may result. The presentation includes a progressive onset of proximal weakness, elevated creatine kinase, and sensorimotor polyneuropathy. Colchicine toxicity can be potentiated by the concomitant use of cholesterol-lowering drugs.[25]

Adverse effects

[edit]

Deaths – both accidental and intentional – have resulted from overdose of colchicine.[25] Typical side effects of moderate doses may include gastrointestinal upset, diarrhea, and neutropenia.[21] High doses can also damage bone marrow, lead to anemia, and cause hair loss. All of these side effects can result from inhibition of mitosis,[41] which may include neuromuscular toxicity and rhabdomyolysis.[25]

Toxicity

[edit]

According to one review, colchicine poisoning by overdose (range of acute doses of 7 to 26 mg) begins with a gastrointestinal phase occurring 10–24 hours after ingestion, followed by multiple organ dysfunction occurring 24 hours to 7 days after ingestion, after which the affected person either declines into multiple organ failure or recovers over several weeks.[42]

Colchicine can be toxic when ingested, inhaled, or absorbed in the eyes.[21] It can cause a temporary clouding of the cornea and be absorbed into the body, causing systemic toxicity. Symptoms of colchicine overdose start 2 to 24 hours after the toxic dose has been ingested, and include burning in the mouth and throat, fever, vomiting, diarrhea, and abdominal pain.[25] This can cause hypovolemic shock due to extreme vascular damage and fluid loss through the gastrointestinal tract, which can be fatal.[42][43]

If the affected persons survive the gastrointestinal phase of toxicity, they may experience multiple organ failure and critical illness. This includes kidney damage, which causes low urine output and bloody urine; low white blood cell counts that can last for several days; anemia; muscular weakness; liver failure; hepatomegaly; bone marrow suppression; thrombocytopenia; and ascending paralysis leading to potentially fatal respiratory failure. Neurologic symptoms are also evident, including seizures, confusion, and delirium; children may experience hallucinations. Recovery may begin within six to eight days and begins with rebound leukocytosis and alopecia as organ functions return to normal.[41][42]

Long-term exposure to colchicine can lead to toxicity, particularly of the bone marrow, kidney, and nerves. Effects of long-term colchicine toxicity include agranulocytosis, thrombocytopenia, low white blood cell counts, aplastic anemia, alopecia, rash, purpura, vesicular dermatitis, kidney damage, anuria, peripheral neuropathy, and myopathy.[41]

No specific antidote for colchicine is known, but supportive care is used in cases of overdose. In the immediate period after an overdose, monitoring for gastrointestinal symptoms, cardiac dysrhythmias, and respiratory depression is appropriate,[41] and may require gastrointestinal decontamination with activated charcoal or gastric lavage.[42][43]

Because colchicine is so toxic, chemists are continuing to try to synthesize derivatives of the molecule that decrease the toxicity. The most important aspect of these derivatives is that they keep the tropolone ring (the ring with the methoxy group and the carbonyl) intact to retain the mechanistic properties of the molecule.[44]

Mechanism of toxicity

[edit]

With overdoses, colchicine becomes toxic as an extension of its cellular mechanism of action via binding to tubulin.[42] Cells so affected undergo impaired protein assembly with reduced endocytosis, exocytosis, cellular motility, and interrupted function of heart cells, culminating in multiple organ failure.[15][42]

Epidemiology

[edit]

In the United States, several hundred cases of colchicine toxicity are reported annually, about 10% of which end with serious morbidity or mortality. Many of these cases are intentional overdoses, but others were accidental; for example, if the drug were not dosed appropriately for kidney function. Most cases of colchicine toxicity occur in adults. Many of these adverse events resulted from the use of intravenous colchicine.[36]

Drug interactions

[edit]

Colchicine interacts with the P-glycoprotein transporter, and the CYP3A4 enzyme involved in drug and toxin metabolism.[25][42] Fatal drug interactions have occurred when colchicine was taken with other drugs that inhibit P-glycoprotein and CYP3A4, such as erythromycin or clarithromycin.[25]

People taking macrolide antibiotics, ketoconazole, or cyclosporine, or those who have liver or kidney disease, should not take colchicine, as these drugs and conditions may interfere with colchicine metabolism and raise its blood levels, potentially increasing its toxicity abruptly.[25][42] Symptoms of toxicity include gastrointestinal upset, fever, muscle pain, low blood cell counts, and organ failure.[21][25] People with HIV/AIDS taking atazanavir, darunavir, fosamprenavir, indinavir, lopinavir, nelfinavir, ritonavir, or saquinavir may experience colchicine toxicity.[25] Grapefruit juice and statins can also increase colchicine concentrations.[25][45]

Pharmacology

[edit]

Mechanism of action

[edit]

In gout, inflammation in joints results from the precipitation of uric acid as needle-like crystals of monosodium urate in and around synovial fluid and soft tissues of joints.[15] These crystal deposits cause inflammatory arthritis, which is initiated and sustained by mechanisms involving various proinflammatory mediators, such as cytokines.[15] Colchicine accumulates in white blood cells and affects them in a variety of ways - decreasing motility, mobilization (especially chemotaxis), and adhesion.[36]

Under preliminary research are various mechanisms by which colchicine may interfere with gout inflammation:

Generally, colchicine appears to inhibit multiple proinflammatory mechanisms, while enabling increased levels of anti-inflammatory mediators.[15] Apart from inhibiting mitosis, colchicine inhibits neutrophil motility and activity, leading to a net anti-inflammatory effect, which has efficacy for inhibiting or preventing gout inflammation.[15][25]

Pharmacokinetics

[edit]

Colchicine appears to be a peripherally selective drug with limited brain uptake due to binding to P-glycoprotein.[46][47][48]

History

[edit]

The plant source of colchicine, the autumn crocus (Colchicum autumnale), was described for treatment of rheumatism and swelling in the Ebers Papyrus (circa 1500 BC), an Egyptian medical text.[49] It is a toxic alkaloid and secondary metabolite.[21][50][25] Colchicum extract was first described as a treatment for gout in De Materia Medica by Pedanius Dioscorides, in the first century AD. Use of the bulb-like corms of Colchicum to treat gout probably dates to around 550 AD, as the "hermodactyl" recommended by Alexander of Tralles. Colchicum corms were used by the Persian physician Avicenna, and were recommended by Ambroise Paré in the 16th century, and appeared in the London Pharmacopoeia of 1618.[51][36] Colchicum use waned over time, likely due[citation needed] to the severe gastrointestinal side effects preparations caused. In 1763, Colchicum was recorded as a remedy for dropsy (now called edema) among other illnesses.[36] Colchicum plants were brought to North America by Benjamin Franklin, who had gout himself and had written humorous doggerel about the disease during his stint as United States Ambassador to France.[52]

Colchicine was first isolated in 1820 by French chemists P. S. Pelletier and J. B. Caventou.[53] In 1833, P. L. Geiger purified an active ingredient, which he named colchicine.[54] It quickly became a popular remedy for gout.[36] The determination of colchicine's structure required decades, although in 1945, Michael Dewar made an important contribution when he suggested that, among the molecule's three rings, two were seven-member rings.[55] Its pain-relieving and anti-inflammatory effects for gout were linked to its ability to bind with tubulin.

The full synthesis of colchicine was achieved by the Swiss organic chemist Albert Eschenmoser in 1959.[56]

United States

[edit]

Colcrys, the Unapproved Drugs Initiative, and controversy

[edit]

In 2006 U.S. Food and Drug Administration (FDA) announced a safety program called the Unapproved Drugs Initiative—through which the FDA sought more rigorous testing of efficacy and safety of colchicine and other unapproved drugs.[57] This program was in response to multiple deaths caused by "unapproved products.".[58][59][60] After the Federal Food, Drug, and Cosmetic Act was signed into law in June 24, 1938, the FDA had the regulatory authority to mandate drugs be reviewed for safety prior to approval. Drugs approved before June 24, 1938, were grandfathered, as long as their manufacturing, ingredients, and labeling remained unchanged. In 1962, the Kefauver-Harris Amendment to the FD&C Act gave the FDA the authority to also require efficacy as a condition for drug approval. Drugs approved after June 24, 1938, but before 1962 had a limited time to be reviewed for efficacy to remain on the market. This was known as the Drug Efficacy Study Implementation (DESI). As of today there are only a handful of drugs still on the DESI list[61] and in 2006, the FDA stated it was not aware of any grandfathered drugs.[62]

By 2006, URL Pharma decided to research colchicine to see if this unapproved product could gain legal FDA approval. Colchicine was a narrow therapeutic index drug that was implicated in numerous death leading to the FDA forcefully removing injectable colchicine from the US Market.[63][64] At this time oral colchicine was being used to treat gout attacks. The only placebo control trial conducted using colchicine for acute gout attacks instructed physicians to give colchicine until pain relief or toxicity.[65] All patients on the colchicine arm had adverse events. Despite its toxicity, unapproved oral colchicine was still prescribed using this dosing regimen. In addition, at this time, oral colchicine was also used to treat the often fatal disease Familial Mediterranean fever (FMF).

In July 2009, the FDA approved colchicine as a monotherapy for the treatment of three different indications (familial Mediterranean fever, acute gout flares, and for the prophylaxis of gout flares[66]). This resulted in a 3-year regulatory market exclusivity in the acute and chronic gout indications and a 7-year exclusivity on the FMF indication. In addition, there are 17 patents on colchicine, listed in the FDA Orange Book[67] which may confer additional exclusivity.

At the time of approval, there were no FDA-approved single-agent colchicine products (brand or generic) in the United States. The unapproved, illegally marketed colchicine products were forcibly removed by the FDA in October 2010.

Controversy
[edit]

The events that led to the approval of Colcrys, the clearance of the illegally sold non-FDA approved colchicine products, Colcrys pricing, and the sale of URL Pharma still are controversial today.

Before the Colcrys approval, unapproved colchicine products were being illegally sold in the United States for under 10 cents a pill. These products were also labeled in an unsafe manner and not manufactured under FDA inspection.[68] URL conducted one Phase 3[69] clinical trial and at least 12 other trials to gain the approval of Colcrys. URL Pharma priced Colcrys at $4.85 a pill drawing the ire of many groups. [70][71]

In 2012, Asia's biggest drugmaker, Takeda Pharmaceutical Co., acquired URL Pharma for $800 million including the rights to Colcrys.

Sources and uses

[edit]

Physical properties

[edit]

Colchicine has a melting point of 142-150 °C. It has a molecular weight of 399.4 grams per mole.[72]

Structure

[edit]

Colchicine has one stereocenter located at carbon 7. The natural configuration of this stereocenter is S. The molecule also contains one chiral axis - the single bond between rings A and C. The natural configuration of this axis is aS. Although colchicine has four stereoisomers, the only one found in nature is the aS,7s configuration.[73]

Light sensitivity

[edit]

Colchicine is a light-sensitive compound, so needs to be stored in a dark bottle. Upon exposure to light, colchicine undergoes photoisomerization and transforms into structural isomers, called lumicolchicine. After this transformation, colchicine is no longer effective in its mechanistic binding to tubulin, so is not effective as a drug.[74]

Regulation

[edit]

It is classified as an extremely hazardous substance in the United States as defined in Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act (42 U.S.C. 11002) and is subject to strict reporting requirements by facilities that produce, store, or use it in significant quantities.[75]

Formulations and dosing

[edit]

Trade names for colchicine are Colcrys or Mitigare, which are manufactured as a dark– and light-blue capsule having a dose of 0.6 mg.[25][76] Colchicine is also prepared as a white, yellow, or purple pill (tablet) having a dose of 0.6 mg.[76]

Colchicine is typically prescribed to mitigate or prevent the onset of gout, or its continuing symptoms and pain, using a low-dose prescription of 0.6 to 1.2 mg per day, or a high-dose amount of up to 4.8 mg in the first 6 hours of a gout episode.[13][25] With an oral dose of 0.6 mg, peak blood levels occur within one to two hours.[50] For treating gout, the initial effects of colchicine occur in a window of 12 to 24 hours, with a peak within 48 to 72 hours.[25] It has a narrow therapeutic window, requiring monitoring of the subject for potential toxicity.[25] Colchicine is not a general pain-relief drug, and is not used to treat pain in other disorders.[25]

Biosynthesis

[edit]

According to laboratory research, the biosynthesis of colchicine involves the amino acids phenylalanine and tyrosine as precursors. Giving radioactive phenylalanine-2-14C to C. byzantinum, another plant of the family Colchicaceae, resulted in its incorporation into colchicine.[77] However, the tropolone ring of colchicine resulted from the expansion of the tyrosine ring. Radioactive feeding experiments of C. autumnale revealed that colchicine can be synthesized biosynthetically from (S)-autumnaline. That biosynthetic pathway occurs primarily through a phenolic coupling reaction involving the intermediate isoandrocymbine. The resulting molecule undergoes O-methylation directed by S-adenosylmethionine. Two oxidation steps followed by the cleavage of the cyclopropane ring lead to the formation of the tropolone ring contained by N-formyldemecolcine. N-formyldemecolcine hydrolyzes then to generate the molecule demecolcine, which also goes through an oxidative demethylation that generates deacetylcolchicine. The molecule of colchicine appears finally after the addition of acetyl-coenzyme A to deacetylcolchicine.[78][79]

A

Purification

[edit]

Colchicine may be purified from Colchicum autumnale (autumn crocus) or Gloriosa superba (glory lily). Concentrations of colchicine in C. autumnale peak in the summer, and range from 0.1% in the flower to 0.8% in the bulb and seeds.[36]

Botanical use and seedless fruit

[edit]

Colchicine is widely used in plant breeding by inducing polyploidy in plant cells to produce new or improved varieties, strains, and cultivars.[19] When used to induce polyploidy in plants, colchicine cream is usually applied to a growth point of the plant, such as an apical tip, shoot, or sucker. Seeds can be presoaked in a colchicine solution before planting. Since chromosome segregation is driven by microtubules, colchicine alters cellular division by inhibiting chromosome segregation during mitosis; half the resulting daughter cells, therefore, contain no chromosomes, while the other half contains double the usual number of chromosomes (i.e., tetraploid instead of diploid), and lead to cell nuclei with double the usual number of chromosomes (i.e., tetraploid instead of diploid).[19] While this would be fatal in most higher animal cells, in plant cells, it is not only usually well-tolerated, but also frequently results in larger, hardier, faster-growing, and in general more desirable plants than the normally diploid parents. For this reason, this type of genetic manipulation is frequently used in breeding plants commercially.[19]

When such a tetraploid plant is crossed with a diploid plant, the triploid offspring are usually sterile (unable to produce fertile seeds or spores), although many triploids can be propagated vegetatively. Growers of annual triploid plants not readily propagated vegetatively cannot produce a second-generation crop from the seeds (if any) of the triploid crop and need to buy triploid seed from a supplier each year. Many sterile triploid plants, including some trees and shrubs, are becoming increasingly valued in horticulture and landscaping because they do not become invasive species and do not drop undesirable fruit and seed litter. In certain species, colchicine-induced triploidy has been used to create "seedless" fruit, such as seedless watermelons (Citrullus lanatus). Since most triploids do not produce pollen themselves, such plants usually require cross-pollination with a diploid parent to induce seedless fruit production.

The ability of colchicine to induce polyploidy can be also exploited to render infertile hybrids fertile, for example in breeding triticale (× Triticosecale) from wheat (Triticum spp.) and rye (Secale cereale). Wheat is typically tetraploid and rye diploid, with their triploid hybrid infertile; treatment of triploid triticale with colchicine gives fertile hexaploid triticale.[80]

References

[edit]
  1. ^ "Health product highlights 2021: Annexes of products approved in 2021". Health Canada. 3 August 2022. Retrieved 25 March 2024.
  2. ^ a b "Colchicine capsule". DailyMed. Retrieved 27 March 2019.
  3. ^ "Drugs@FDA: FDA-Approved Drugs". www.accessdata.fda.gov. Retrieved 29 May 2024.
  4. ^ "Drugs@FDA: FDA-Approved Drugs". www.accessdata.fda.gov. Retrieved 29 May 2024.
  5. ^ "Drugs@FDA: FDA-Approved Drugs". www.accessdata.fda.gov. Retrieved 29 May 2024.
  6. ^ Schachner LA, Hansen RC (2011). Pediatric Dermatology E-Book. Elsevier Health Sciences. p. 177. ISBN 978-0-7234-3665-2.
  7. ^ "Drugs@FDA: FDA-Approved Drugs". www.accessdata.fda.gov. Retrieved 29 May 2024.
  8. ^ Khanna D, Fitzgerald JD, Khanna PP, Bae S, Singh MK, Neogi T, et al. (October 2012). "2012 American College of Rheumatology guidelines for management of gout. Part 1: systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia". Arthritis Care & Research. 64 (10): 1431–1446. doi:10.1002/acr.21772. PMC 3683400. PMID 23024028.
  9. ^ Khanna D, Khanna PP, Fitzgerald JD, Singh MK, Bae S, Neogi T, et al. (October 2012). "2012 American College of Rheumatology guidelines for management of gout. Part 2: therapy and antiinflammatory prophylaxis of acute gouty arthritis". Arthritis Care & Research. 64 (10): 1447–1461. doi:10.1002/acr.21773. PMC 3662546. PMID 23024029.
  10. ^ Hutchison SJ (2009). Pericardial Diseases: Clinical Diagnostic Imaging Atlas with DVD. Elsevier Health Sciences. p. 58. ISBN 978-1-4160-5274-6.
  11. ^ a b c "Colchicine Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 27 March 2019.
  12. ^ "FDA Enforcement Against Injectable Colchicine". The Rheumatologist. May 2008. Retrieved 29 May 2024.
  13. ^ a b "Colchicine for acute gout: updated information about dosing and drug interactions". National Prescribing Service, Australia. 14 May 2010. Archived from the original on 30 June 2012. Retrieved 14 May 2010.
  14. ^ a b British national formulary: BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 1085–1086. ISBN 978-0-85711-338-2. "Colchicine". British national formulary. National Institute for Health and Care Excellence (NICE). Retrieved 26 January 2024. Available online in UK only
  15. ^ a b c d e f g h i j Dalbeth N, Lauterio TJ, Wolfe HR (October 2014). "Mechanism of action of colchicine in the treatment of gout". Clinical Therapeutics. 36 (10): 1465–1479. doi:10.1016/j.clinthera.2014.07.017. PMID 25151572.
  16. ^ Wall WJ (2015). The Search for Human Chromosomes: A History of Discovery. Springer. p. 88. ISBN 978-3-319-26336-6.
  17. ^ "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.
  18. ^ "Colchicine Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.
  19. ^ a b c d Griffiths AJ, Gelbart WM, Miller JH (1999). "Modern Genetic Analysis: Changes in Chromosome Number". Modern Genetic Analysis. W. H. Freeman, New York.
  20. ^ Chen LX, Schumacher HR (October 2008). "Gout: an evidence-based review". Journal of Clinical Rheumatology. 14 (5 Suppl): S55 – S62. doi:10.1097/RHU.0b013e3181896921. PMID 18830092. S2CID 6644013.
  21. ^ a b c d e "Colcrys (colchicine, USP) tablets 0.6 mg. Drug Approval Package". US Food and Drug Administration. 17 February 2010. Retrieved 19 August 2018.
  22. ^ "Information for Healthcare Professionals: New Safety Information for Colchicine (marketed as Colcrys)". U.S. Food and Drug Administration.
  23. ^ Laubscher T, Dumont Z, Regier L, Jensen B (December 2009). "Taking the stress out of managing gout". Canadian Family Physician. 55 (12): 1209–1212. PMC 2793228. PMID 20008601.
  24. ^ a b McKenzie BJ, Wechalekar MD, Johnston RV, Schlesinger N, Buchbinder R (August 2021). "Colchicine for acute gout". The Cochrane Database of Systematic Reviews. 2021 (8): CD006190. doi:10.1002/14651858.CD006190.pub3. PMC 8407279. PMID 34438469.
  25. ^ a b c d e f g h i j k l m n o p q r s t u v "Colchicine". Drugs.com. 1 January 2017. Retrieved 19 August 2018.
  26. ^ Shekelle PG, Newberry SJ, FitzGerald JD, Motala A, O'Hanlon CE, Tariq A, et al. (January 2017). "Management of Gout: A Systematic Review in Support of an American College of Physicians Clinical Practice Guideline". Annals of Internal Medicine. 166 (1): 37–51. doi:10.7326/M16-0461. PMID 27802478.
  27. ^ Qaseem A, Harris RP, Forciea MA, Denberg TD, Barry MJ, Boyd C, et al. (January 2017). "Management of Acute and Recurrent Gout: A Clinical Practice Guideline From the American College of Physicians". Annals of Internal Medicine. 166 (1): 58–68. doi:10.7326/M16-0570. PMID 27802508.
  28. ^ Roddy E, Bajpai R, Forrester H, Partington RJ, Mallen CD, Clarson LE, et al. (December 2023). "Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink". Annals of the Rheumatic Diseases. 82 (12): 1618–1625. doi:10.1136/ard-2023-224154. PMC 10646835. PMID 37788904.
  29. ^ "How common are side-effects of treatment to prevent gout flares when starting allopurinol?". NIHR Evidence. 6 February 2024. doi:10.3310/nihrevidence_62005. S2CID 267539627.
  30. ^ "Home". LODOCO. Retrieved 29 May 2024.
  31. ^ a b "Lodoco". Drugs.com. 23 June 2023. Retrieved 19 February 2024.
  32. ^ a b c Nelson K, Fuster V, Ridker PM (August 2023). "Low-Dose Colchicine for Secondary Prevention of Coronary Artery Disease: JACC Review Topic of the Week". Journal of the American College of Cardiology. 82 (7): 648–660. doi:10.1016/j.jacc.2023.05.055. PMID 37558377. S2CID 260715494.
  33. ^ a b c Cocco G, Chu DC, Pandolfi S (December 2010). "Colchicine in clinical medicine. A guide for internists". European Journal of Internal Medicine. 21 (6): 503–508. doi:10.1016/j.ejim.2010.09.010. PMID 21111934.
  34. ^ Puéchal X, Terrier B, Mouthon L, Costedoat-Chalumeau N, Guillevin L, Le Jeunne C (March 2014). "Relapsing polychondritis". Joint Bone Spine. 81 (2): 118–124. doi:10.1016/j.jbspin.2014.01.001. PMID 24556284. S2CID 205754989.
  35. ^ Alabed S, Cabello JB, Irving GJ, Qintar M, Burls A, Nelson L (August 2014). "Colchicine for pericarditis". The Cochrane Database of Systematic Reviews. 2014 (8): CD010652. doi:10.1002/14651858.CD010652.pub2. PMC 10645160. PMID 25164988.
  36. ^ a b c d e f g h i j Hoffman RS, Nelson LS, Goldfrank LR, Howland MA, Lewin NA, Smith SW (11 April 2019). Goldfrank's toxicologic emergencies (Eleventh ed.). New York: McGraw-Hill. ISBN 978-1-259-85961-8. OCLC 1020416505.
  37. ^ Portincasa P (2016). "Colchicine, Biologic Agents and More for the Treatment of Familial Mediterranean Fever. The Old, the New, and the Rare". Current Medicinal Chemistry. 23 (1): 60–86. doi:10.2174/0929867323666151117121706. PMID 26572612.
  38. ^ Lennerz C, Barman M, Tantawy M, Sopher M, Whittaker P (December 2017). "Colchicine for primary prevention of atrial fibrillation after open-heart surgery: Systematic review and meta-analysis" (PDF). International Journal of Cardiology. 249: 127–137. doi:10.1016/j.ijcard.2017.08.039. PMID 28918897.
  39. ^ Imazio M, Andreis A, Brucato A, Adler Y, De Ferrari GM (October 2020). "Colchicine for acute and chronic coronary syndromes". Heart. 106 (20): 1555–1560. doi:10.1136/heartjnl-2020-317108. PMID 32611559. S2CID 220305546.
  40. ^ Nidorf SM, Fiolet AT, Mosterd A, Eikelboom JW, Schut A, Opstal TS, et al. (November 2020). "Colchicine in Patients with Chronic Coronary Disease". The New England Journal of Medicine. 383 (19): 1838–1847. doi:10.1056/NEJMoa2021372. hdl:2066/229130. PMID 32865380.
  41. ^ a b c d "CDC - The Emergency Response Safety and Health Database: Biotoxin: Colchicine". Centers for Disease Control and Prevention, US Department of Health and Human Services. Retrieved 31 December 2015.
  42. ^ a b c d e f g h Finkelstein Y, Aks SE, Hutson JR, Juurlink DN, Nguyen P, Dubnov-Raz G, et al. (June 2010). "Colchicine poisoning: the dark side of an ancient drug". Clinical Toxicology. 48 (5): 407–414. doi:10.3109/15563650.2010.495348. PMID 20586571. S2CID 33905426.
  43. ^ a b Doogue M (2014). "Colchicine – extremely toxic in overdose" (PDF). Christchurch and Canterbury District Health Board, New Zealand. Retrieved 23 August 2018.
  44. ^ Jankowski W, Kurek J, Barczyński P, Hoffmann M (April 2017). "Quantum-chemical, NMR, FT IR, and ESI MS studies of complexes of colchicine with Zn(II)". Journal of Molecular Modeling. 23 (4): 127. doi:10.1007/s00894-017-3306-z. PMC 5393104. PMID 28321655.
  45. ^ Schwier NC, Cornelio CK, Boylan PM (April 2022). "A systematic review of the drug-drug interaction between statins and colchicine: Patient characteristics, etiologies, and clinical management strategies". Pharmacotherapy. 42 (4): 320–333. doi:10.1002/phar.2674. PMID 35175631. S2CID 246903117.
  46. ^ Niel E, Scherrmann JM (December 2006). "Colchicine today". Joint Bone Spine. 73 (6): 672–8. doi:10.1016/j.jbspin.2006.03.006. PMID 17067838.
  47. ^ Drion N, Lemaire M, Lefauconnier JM, Scherrmann JM (October 1996). "Role of P-glycoprotein in the blood-brain transport of colchicine and vinblastine". J Neurochem. 67 (4): 1688–93. doi:10.1046/j.1471-4159.1996.67041688.x. PMID 8858954. S2CID 38446612.
  48. ^ Cisternino S, Rousselle C, Debray M, Scherrmann JM (October 2003). "In vivo saturation of the transport of vinblastine and colchicine by P-glycoprotein at the rat blood-brain barrier". Pharm Res. 20 (10): 1607–11. doi:10.1023/a:1026187301648. PMID 14620515. S2CID 10193442.
  49. ^ Graham W, Roberts JB (March 1953). "Intravenous colchicine in the management of gouty arthritis". Annals of the Rheumatic Diseases. 12 (1): 16–19. doi:10.1136/ard.12.1.16. PMC 1030428. PMID 13031443.
  50. ^ a b "Colcrys (colchicine). Summary review for regulatory action" (PDF). Center for Drug Evaluation and Research, US Food and Drug Administration. 30 July 2009. Retrieved 19 August 2018.
  51. ^ Hartung EF (September 1954). "History of the use of colchicum and related medicaments in gout; with suggestions for further research". Annals of the Rheumatic Diseases. 13 (3): 190–200. doi:10.1136/ard.13.3.190. PMC 1006735. PMID 13198053. (free BMJ registration required)
  52. ^ Ebadi MS (2007). Pharmacodynamic basis of herbal medicine. CRC Press. ISBN 978-0-8493-7050-2.
  53. ^ Pelletier PS, Caventou JB (1820). "Examen chimique des plusieurs végétaux de la famille des colchicées, et du principe actif qu'ils renferment. [Cévadille (veratrum sabadilla); hellébore blanc (veratrum album); colchique commun (colchicum autumnale)]" [Chemical examination of several plants of the meadow saffron family, and of the active principle that they contain.]. Annales de Chimie et de Physique. 14: 69–81.
  54. ^ Geiger PL (1833). "Ueber einige neue giftige organische Alkalien" [On some new poisonous organic alkalis] (PDF). Annalen der Pharmacie (in German). 7 (3): 269–280. doi:10.1002/jlac.18330070312.; colchicine is discussed on pages 274-276
  55. ^ Dewar MJ (3 February 1945). "Structure of colchicine". Letters to Editor. Nature. 155 (3927): 141–142. Bibcode:1945Natur.155..141D. doi:10.1038/155141d0. S2CID 4074312. Dewar did not prove the structure of colchicine; he merely suggested that it contained two seven-membered rings. Colchicine's structure was determined by X-ray crystallography in 1952 King MV, de Vries JL, Pepinsky R (July 1952). "An x-ray diffraction determination of the chemical structure of colchicine". Acta Crystallographica. 5 (4): 437–440. Bibcode:1952AcCry...5..437K. doi:10.1107/S0365110X52001313. Its total synthesis was first accomplished in 1959 Eschenmoser A (1959). "Synthese des Colchicins". Angewandte Chemie. 71 (20): 637–640. Bibcode:1959AngCh..71..637S. doi:10.1002/ange.19590712002.
  56. ^ Albert Eschenmoser The Franklin Institute. fi.edu. Accessed 24 September 2023.
  57. ^ "FDA Unapproved Drugs Initiative". Food and Drug Administration.
  58. ^ "FDA Moves In On Unapproved Cough Suppressant Hydrocodone Products". www.medicalnewstoday.com. 29 September 2007. Retrieved 29 May 2024.
  59. ^ "Unapproved Drugs Called 'Threat'". Washington Post. 31 January 2024. ISSN 0190-8286. Retrieved 29 May 2024.
  60. ^ "AP: Millions Spent On Unapproved Medicines - CBS News". www.cbsnews.com. 24 November 2008. Retrieved 29 May 2024.
  61. ^ Center for Drug Evaluation and Research (16 May 2024). "Drug Efficacy Study Implementation (DESI)". FDA.
  62. ^ Nasr A, Lauterio TJ, Davis MW (October 2011). "Unapproved drugs in the United States and the Food and Drug Administration". Advances in Therapy. 28 (10): 842–856. doi:10.1007/s12325-011-0059-4. PMID 21894470.
  63. ^ "Deaths from Intravenous Colchicine Resulting from a Compounding Pharmacy Error --- Oregon and Washington, 2007". www.cdc.gov. Retrieved 29 May 2024.
  64. ^ "Federal Register / Vol. 73, No. 27 / Page 7565" (PDF). govinfo.gov. 8 February 2008. Retrieved 29 May 2024.
  65. ^ Ahern MJ, Reid C, Gordon TP, McCredie M, Brooks PM, Jones M (June 1987). "Does colchicine work? The results of the first controlled study in acute gout". Australian and New Zealand Journal of Medicine. 17 (3): 301–304. doi:10.1111/j.1445-5994.1987.tb01232.x. PMID 3314832.
  66. ^ "FDA Approves Colchicine With Drug Interaction and Dose Warnings". July 2009.
  67. ^ "Orange Book: Approved Drug Products with Therapeutic Equivalence Evaluations". www.accessdata.fda.gov. Retrieved 30 May 2024.
  68. ^ Center for Drug Evaluation and Research (2009). "Colchicine (marketed as Colcrys) Information". FDA.
  69. ^ Terkeltaub RA, Furst DE, Bennett K, Kook KA, Crockett RS, Davis MW (April 2010). "High versus low dosing of oral colchicine for early acute gout flare: Twenty-four-hour outcome of the first multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-comparison colchicine study". Arthritis and Rheumatism. 62 (4): 1060–1068. doi:10.1002/art.27327. PMID 20131255. S2CID 205424044.
  70. ^ Kesselheim AS, Solomon DH (June 2010). "Incentives for drug development--the curious case of colchicine". The New England Journal of Medicine. 362 (22): 2045–2047. doi:10.1056/NEJMp1003126. PMID 20393164.
  71. ^ Langreth R, Koons C (6 October 2015). "2,000% Drug Price Surge Is a Side Effect of FDA Safety Program". Bloomberg.com. Bloomberg. Retrieved 27 October 2015.
  72. ^ "Colchicine". PubChem. National Center for Biotechnology Information. Retrieved 7 November 2021.
  73. ^ Sapra S, Bhalla Y, Sharma S, Singh G, Nepali K, Budhiraja A, et al. (13 May 2012). "Colchicine and its various physicochemical and biological aspects". Medicinal Chemical Research. 22 (2): 531. doi:10.1007/s00044-012-0077-z. S2CID 13211030. Retrieved 7 November 2021.
  74. ^ Sagorin C, Ertel NH, Wallace SL (March 1972). "Photoisomerization of colchicine. Loss of significant antimitotic activity in human lymphocytes". Arthritis and Rheumatism. 15 (2): 213–217. doi:10.1002/art.1780150213. PMID 5027606.
  75. ^ "40 CFR Appendix A to Part 355, The List of Extremely Hazardous Substances and Their Threshold Planning Quantities". LII / Legal Information Institute. Retrieved 11 March 2018.
  76. ^ a b "Colchicine images". Drugs.com. 6 August 2018. Retrieved 21 August 2018.
  77. ^ Leete E (1963). "The biosynthesis of the alkaloids of Colchicum: The incorporation of phenylalaline-2-C14 into colchicine and demecolcine". J. Am. Chem. Soc. 85 (22): 3666–3669. doi:10.1021/ja00905a030.
  78. ^ Herbert RB (February 2001). "The biosynthesis of plant alkaloids and nitrogenous microbial metabolites". Natural Product Reports. 18 (1): 50–65. doi:10.1039/A809393H. PMID 11245400.
  79. ^ Dewick PM (2009). Medicinal natural products: A biosynthetic approach. Wiley. pp. 360–362.
  80. ^ Dermen H, Emsweller SL (1961). "The use of colchicine in plant breeding". archive.org. Retrieved 26 April 2016.
[edit]
Wikimedia Commons has media related to Colchicine.
Retrieved from "https://wiki.riteme.site/w/index.php?title=Colchicine&oldid=1262957528"