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Chemerin peptide

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retinoic acid receptor responder (tazarotene induced) 2
Identifiers
SymbolRARRES2
Alt. symbolschemerin
NCBI gene5919
HGNC9868
OMIM601973
RefSeqNM_002889
UniProtQ99969
Other data
LocusChr. 7 q36.1
Search for
StructuresSwiss-model
DomainsInterPro

Chemerin peptides are short peptides (on the order of 9 amino acids) that are produced from the carboxyl terminus of the chemokine chemerin. They display the same activities as chemerin, although at higher efficacy and potency.[1]

A particular synthetic chemerin-derived peptide, termed C15, was developed at Oxford University. It showed anti-inflammatory activities. Intraperitoneal administration of C15 (0.32 ng/kg) to mice before zymosan challenge conferred significant protection against zymosan-induced peritonitis, suppressing neutrophil (63%) and monocyte (62%) recruitment with a concomitant reduction in proinflammatory mediator expression.[2]

C15 was found to promote phagocytosis and efferocytosis in peritoneal macrophages at picomolar concentrations. C15 enhanced macrophage clearance of microbial particles and apoptotic cells by factor of 360% in vitro [3]

References

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  1. ^ Wittamer V, Grégoire F, Robberecht P, Vassart G, Communi D, Parmentier M (March 2004). "The C-terminal nonapeptide of mature chemerin activates the chemerin receptor with low nanomolar potency". J. Biol. Chem. 279 (11): 9956–62. doi:10.1074/jbc.M313016200. PMID 14701797.
  2. ^ cash, J; Cash JL; Hart R; Russ A; Dixon JP; Colledge WH; Doran J; Hendrick AG; Carlton MB; Greaves DR (Apr 2008). "Synthetic chemerin-derived peptides suppress inflammation through ChemR23". J. Exp. Med. 205 (4): 767–75. doi:10.1084/jem.20071601. PMC 2292217. PMID 18391062.
  3. ^ Cash, J; Greaves DR (May 2010). "Chemerin peptides promote phagocytosis in a ChemR23 and Syk dependent manner". J. Immunol. 184 (9): 5315–24. doi:10.4049/jimmunol.0903378. PMC 4237835. PMID 20363975.

See also

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