CTTNBP2

CTTNBP2
Identifiers
Aliases	CTTNBP2, C7orf8, CORTBP2, Orf4, cortactin binding protein 2
External IDs	OMIM: 609772; MGI: 1353467; HomoloGene: 14125; GeneCards: CTTNBP2; OMA:CTTNBP2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	117,874,139 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	18,514,842 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; ganglionic eminence; ; subthalamic nucleus; ; inferior ganglion of vagus nerve; ; pars reticulata; ; lateral nuclear group of thalamus; ; primary visual cortex; ; endothelial cell; ; external globus pallidus; ; C1 segment;
	Top expressed in
	lateral septal nucleus; ; subiculum; ; lateral geniculate nucleus; ; piriform cortex; ; medial geniculate nucleus; ; superior cervical ganglion; ; medial dorsal nucleus; ; olfactory tubercle; ; visual cortex; ; anterior amygdaloid area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding;
Cellular component	cytoplasm; dendritic spine; cell projection; cell cortex; synaptic vesicle; postsynaptic actin cytoskeleton; glutamatergic synapse;
Biological process	brain development; regulation of synapse organization; regulation of modification of postsynaptic actin cytoskeleton;
	Sources:Amigo / QuickGO
Orthologs
	83992
	30785
	ENSG00000077063
	ENSMUSG00000000416
	Q8WZ74
	B9EJA2
	NM_033427; NM_001363349; NM_001363350; NM_001363351
	NM_080285
	NP_219499; NP_001350278; NP_001350279; NP_001350280
	NP_525024
	Wikidata
View/Edit Human	View/Edit Mouse

Cortactin-binding protein 2 is a protein that in humans is encoded by the CTTNBP2 gene.^[5]^[6]

Function

This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin cytoskeleton.^[6]

Interactions

CTTNBP2 has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000077063 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000416 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cheung J, Petek E, Nakabayashi K, Tsui LC, Vincent JB, Scherer SW (Nov 2001). "Identification of the human cortactin-binding protein-2 gene from the autism candidate region at 7q31". Genomics. 78 (1–2): 7–11. doi:10.1006/geno.2001.6651. PMID 11707066.
^ ^a ^b "Entrez Gene: CTTNBP2 cortactin binding protein 2".
^ ^a ^b ^c ^d ^e Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell. Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.

External links

Human CTTNBP2 genome location and CTTNBP2 gene details page in the UCSC Genome Browser.

Ohoka Y, Takai Y (1998). "Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90". Genes Cells. 3 (9): 603–12. doi:10.1046/j.1365-2443.1998.00216.x. PMID 9813110. S2CID 22413036.
Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
Zink D, Amaral MD, Englmann A, Lang S, Clarke LA, Rudolph C, Alt F, Luther K, Braz C, Sadoni N, Rosenecker J, Schindelhauer D (2004). "Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei". J. Cell Biol. 166 (6): 815–25. doi:10.1083/jcb.200404107. PMC 2172106. PMID 15364959.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000077063 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000416 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11707066-5] Cheung J, Petek E, Nakabayashi K, Tsui LC, Vincent JB, Scherer SW (Nov 2001). "Identification of the human cortactin-binding protein-2 gene from the autism candidate region at 7q31". Genomics. 78 (1–2): 7–11. doi:10.1006/geno.2001.6651. PMID 11707066.

[entrez-6] "Entrez Gene: CTTNBP2 cortactin binding protein 2".

[pmid18782753-7] Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell. Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.

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Function

Interactions

References

External links

Further reading