CTPS2

CTPS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2V4U, 2VKT, 3IHL
Identifiers
Aliases	CTPS2, CTP synthase 2, GATD5B
External IDs	OMIM: 300380; MGI: 1933185; HomoloGene: 115908; GeneCards: CTPS2; OMA:CTPS2 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xp22.2 Start 16,587,999 bp End 16,712,936 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X F4 Start 161,684,234 bp End 161,815,504 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa ventricular zone body of pancreas canal of the cervix right ovary left ovary ganglionic eminence Achilles tendon duodenum right uterine tube Top expressed in granulocyte genital tubercle endothelial cell of lymphatic vessel ventricular zone tail of embryo right kidney external carotid artery internal carotid artery facial motor nucleus proximal tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ligase activity nucleotide binding protein binding ATP binding CTP synthase activity identical protein binding Cellular component cytosol cytoplasm cytoophidium Biological process pyrimidine nucleotide metabolic process glutamine metabolic process 'de novo' CTP biosynthetic process pyrimidine nucleotide biosynthetic process nucleobase-containing small molecule interconversion CTP biosynthetic process pyrimidine nucleobase biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56474 55936 Ensembl ENSG00000047230 ENSMUSG00000031360 UniProt Q9NRF8 P70303 RefSeq (mRNA) NM_001144002 NM_019857 NM_175859 NM_001168568 NM_001168569 NM_001168571 NM_018737 NM_001358398 RefSeq (protein) NP_001137474 NP_062831 NP_787055 NP_001162040 NP_001162041 NP_001162043 NP_061207 NP_001345327 Location (UCSC) Chr X: 16.59 – 16.71 Mb Chr X: 161.68 – 161.82 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

CTP synthase 2 is an enzyme that in humans is encoded by the CTPS2 gene.

The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate.

This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein.

Thus, this protein is an attractive target for selective chemotherapy. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.

External links

• Human CTPS2 genome location and CTPS2 gene details page in the UCSC Genome Browser.

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Han GS, Sreenivas A, Choi MG, et al. (2006). "Expression of Human CTP Synthetase in Saccharomyces cerevisiae Reveals Phosphorylation by Protein Kinase A". J. Biol. Chem. 280 (46): 38328–36. doi:10.1074/jbc.M509622200. PMC 1400552. PMID 16179339.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.