Collectin-10

COLEC10
Identifiers
Aliases	COLEC10, CLL1, CL-34, collectin subfamily member 10, 3MC3, CL-10
External IDs	OMIM: 607620; MGI: 3606482; HomoloGene: 31381; GeneCards: COLEC10; OMA:COLEC10 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	119,108,455 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	54,329,754 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; testicle; ; stromal cell of endometrium; ; gonad; ; right lung; ; gallbladder; ; left ventricle; ; islet of Langerhans; ; apex of heart; ; right coronary artery;
	Top expressed in
	migratory enteric neural crest cell; ; liver; ; left lobe of liver; ; yolk sac; ; small intestine; ; ileum; ; duodenum; ; abdominal wall; ; jejunum; ; Paneth cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	mannose binding; carbohydrate binding; serine-type endopeptidase activity; chemoattractant activity; monosaccharide binding;
Cellular component	collagen; extracellular region; extracellular space; cytoplasm; Golgi apparatus;
Biological process	complement activation; proteolysis; complement activation, lectin pathway; positive chemotaxis; cranial skeletal system development; developmental process;
	Sources:Amigo / QuickGO
Orthologs
	10584
	239447
	ENSG00000184374
	ENSMUSG00000038591
	Q9Y6Z7
	Q8CF98
	NM_006438; NM_001324095
	NM_173422
	NP_001311024; NP_006429
	NP_775598
	Wikidata
View/Edit Human	View/Edit Mouse

Collectin-10, also known as collectin liver 1, is a collectin protein that in humans is encoded by the COLEC10 gene. Its structure is similar to mannan-binding lectin (MBL).^[5]

Collectin liver 1 (CL-L1) show very similar carbohydrate selectivity as MBL. Two other discovered collectins include collectin placenta 1 (CL-P1) and collectin kidney 1 (CL-K1). CL-L1's location found to be on chromosome 8 q23-24.1. Research concluded CL-L1 to be a serum protein.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184374 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038591 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Laursen TL, Sandahl TD, Støy S, Schiødt FV, Lee WM, Vilstrup H, Thiel S, Grønbaek H (March 2015). "Circulating mannan-binding lectin, M-, L-, H-ficolin and collectin-liver-1 levels in patients with acute liver failure". Liver International. 35 (3): 756–63. doi:10.1111/liv.12682. PMC 4329085. PMID 25203057.
^ Axelgaard E, Jensen L, Dyrlund TF, Nielsen HJ, Enghild JJ, Thiel S, Jensenius JC (August 2013). "Investigations on collectin liver 1". The Journal of Biological Chemistry. 288 (32): 23407–20. doi:10.1074/jbc.M113.492603. PMC 3743509. PMID 23814060.

External links

collectin+liver+1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000184374 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038591 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Laursen TL, Sandahl TD, Støy S, Schiødt FV, Lee WM, Vilstrup H, Thiel S, Grønbaek H (March 2015). "Circulating mannan-binding lectin, M-, L-, H-ficolin and collectin-liver-1 levels in patients with acute liver failure". Liver International. 35 (3): 756–63. doi:10.1111/liv.12682. PMC 4329085. PMID 25203057.

[6] Axelgaard E, Jensen L, Dyrlund TF, Nielsen HJ, Enghild JJ, Thiel S, Jensenius JC (August 2013). "Investigations on collectin liver 1". The Journal of Biological Chemistry. 288 (32): 23407–20. doi:10.1074/jbc.M113.492603. PMC 3743509. PMID 23814060.

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