CIAO1

CIAO1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3FM0
Identifiers
Aliases	CIAO1, CIA1, WDR39, cytosolic iron-sulfur assembly component 1
External IDs	OMIM: 604333; MGI: 1346998; HomoloGene: 55850; GeneCards: CIAO1; OMA:CIAO1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	96,274,173 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	127,089,736 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; left adrenal cortex; ; granulocyte; ; ganglionic eminence; ; cerebellar hemisphere; ; ventricular zone; ; body of pancreas; ; right frontal lobe; ; putamen; ; nucleus accumbens;
	Top expressed in
	right ventricle; ; right kidney; ; muscle of thigh; ; interventricular septum; ; medial ganglionic eminence; ; dentate gyrus of hippocampal formation granule cell; ; human kidney; ; lip; ; adrenal gland; ; seminal vesicula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	CIA complex; MMXD complex; cytoplasm;
Biological process	regulation of transcription by RNA polymerase II; iron-sulfur cluster assembly; positive regulation of cell population proliferation; chromosome segregation; protein maturation by iron-sulfur cluster transfer;
	Sources:Amigo / QuickGO
Orthologs
	9391
	26371
	ENSG00000144021
	ENSMUSG00000003662
	O76071
	Q99KN2
	NM_004804
	NM_025296
	NP_004795
	NP_079572
	Wikidata
View/Edit Human	View/Edit Mouse

Probable cytosolic iron-sulfur protein assembly protein CIAO1 is a protein that in humans is encoded by the CIAO1 gene.^[5]^[6]^[7] CIAO1 forms a complex with FAM96B, MMS19, the co-chaperone HSC20 and the scaffold protein ISCU in order to assist iron-sulfur cluster incorporation into cytoplasmic and nuclear iron-sulfur proteins.^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000144021 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003662 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Johnstone RW, Wang J, Tommerup N, Vissing H, Roberts T, Shi Y (May 1998). "Ciao 1 is a novel WD40 protein that interacts with the tumor suppressor protein WT1". The Journal of Biological Chemistry. 273 (18): 10880–7. doi:10.1074/jbc.273.18.10880. PMID 9556563.
^ Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (September 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
^ "Entrez Gene: CIAO1 cytosolic iron-sulfur protein assembly 1 homolog (S. cerevisiae)".
^ Gari K, León Ortiz AM, Borel V, Flynn H, Skehel JM, Boulton SJ (July 2012). "MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism". Science. 337 (6091): 243–5. Bibcode:2012Sci...337..243G. doi:10.1126/science.1219664. PMID 22678361. S2CID 26605576.
^ Kim KS, Maio N, Singh A, Rouault TA (March 2018). "Cytosolic HSC20 integrates de novo iron-sulfur cluster biogenesis with the CIAO1-mediated transfer to recipients". Human Molecular Genetics. 27 (5): 837–852. doi:10.1093/hmg/ddy004. PMC 6075588. PMID 29309586.

External links

Human CIAO1 genome location and CIAO1 gene details page in the UCSC Genome Browser.

Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H (November 2006). "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation". Nature Cell Biology. 8 (11): 1277–83. doi:10.1038/ncb1490. hdl:10397/34293. PMID 17041588. S2CID 22180568.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000144021 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003662 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9556563-5] Johnstone RW, Wang J, Tommerup N, Vissing H, Roberts T, Shi Y (May 1998). "Ciao 1 is a novel WD40 protein that interacts with the tumor suppressor protein WT1". The Journal of Biological Chemistry. 273 (18): 10880–7. doi:10.1074/jbc.273.18.10880. PMID 9556563.

[pmid10493829-6] Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (September 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.

[entrez-7] "Entrez Gene: CIAO1 cytosolic iron-sulfur protein assembly 1 homolog (S. cerevisiae)".

[8] Gari K, León Ortiz AM, Borel V, Flynn H, Skehel JM, Boulton SJ (July 2012). "MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism". Science. 337 (6091): 243–5. Bibcode:2012Sci...337..243G. doi:10.1126/science.1219664. PMID 22678361. S2CID 26605576.

[9] Kim KS, Maio N, Singh A, Rouault TA (March 2018). "Cytosolic HSC20 integrates de novo iron-sulfur cluster biogenesis with the CIAO1-mediated transfer to recipients". Human Molecular Genetics. 27 (5): 837–852. doi:10.1093/hmg/ddy004. PMC 6075588. PMID 29309586.

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References

External links

Further reading