CHMP2A

CHMP2A
Identifiers
Aliases	CHMP2A, BC-2, BC2, CHMP2, VPS2, VPS2A, charged multivesicular body protein 2A
External IDs	OMIM: 610893; MGI: 1916203; HomoloGene: 6382; GeneCards: CHMP2A; OMA:CHMP2A - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.43 Start 58,551,452 bp End 58,555,105 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 A1|7 Start 12,765,937 bp End 12,768,734 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon right adrenal gland right adrenal cortex left adrenal gland left adrenal cortex oral cavity olfactory zone of nasal mucosa skin of leg apex of heart gastric mucosa Top expressed in corneal stroma saccule seminal vesicula superior surface of tongue arcuate nucleus olfactory epithelium neural layer of retina left colon otic vesicle skin of external ear More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein domain specific binding phosphatidylcholine binding protein binding Cellular component cytosol endosome membrane late endosome membrane membrane coat extracellular exosome ESCRT III complex nuclear envelope chromatin multivesicular body Biological process regulation of centrosome duplication protein polymerization viral budding via host ESCRT complex protein heterooligomerization nucleus organization viral life cycle establishment of protein localization negative regulation of centriole elongation membrane invagination multivesicular body assembly negative regulation of cell death regulation of mitotic spindle assembly endosomal transport transport protein transport positive regulation of exosomal secretion septum digestion after cytokinesis mitotic metaphase plate congression protein homooligomerization vacuolar transport regulation of viral process ESCRT III complex disassembly nuclear membrane reassembly exit from mitosis macroautophagy endosome transport via multivesicular body sorting pathway late endosome to vacuole transport midbody abscission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27243 68953 Ensembl ENSG00000130724 ENSMUSG00000033916 UniProt O43633 Q9DB34 RefSeq (mRNA) NM_014453 NM_198426 NM_026885 NM_001360730 NM_001360731 NM_001360733 RefSeq (protein) NP_055268 NP_940818 NP_081161 NP_001347659 NP_001347660 NP_001347662 Location (UCSC) Chr 19: 58.55 – 58.56 Mb Chr 7: 12.77 – 12.77 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Charged multivesicular body protein 2a is a protein that in humans is encoded by the CHMP2A gene.

It is a reference gene.

External links

• Human CHMP2A genome location and CHMP2A gene details page in the UCSC Genome Browser.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Strack B, Calistri A, Craig S, et al. (2003). "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding". Cell. 114 (6): 689–99. doi:10.1016/S0092-8674(03)00653-6. PMID 14505569. S2CID 10733770.
• von Schwedler UK, Stuchell M, Müller B, et al. (2003). "The protein network of HIV budding". Cell. 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570. S2CID 16894972.
• Martin-Serrano J, Yarovoy A, Perez-Caballero D, et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. Bibcode:2003PNAS..10012414M. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Tsang HT, Connell JW, Brown SE, et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.