CENPM

CENPM
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4P0T, 4WAU
Identifiers
Aliases	CENPM, C22orf18, CENP-M, PANE1, bK250D10.2, centromere protein M
External IDs	OMIM: 610152; MGI: 1913820; HomoloGene: 11438; GeneCards: CENPM; OMA:CENPM - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	41,947,152 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	82,128,949 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; right uterine tube; ; gonad; ; ventricular zone; ; ganglionic eminence; ; epithelium of bronchus; ; bronchial epithelial cell; ; testicle; ; bone marrow; ; appendix;
	Top expressed in
	morula; ; ventricular zone; ; primary oocyte; ; secondary oocyte; ; embryo; ; embryo; ; medial ganglionic eminence; ; zygote; ; yolk sac; ; fetal liver hematopoietic progenitor cell;
	More reference expression data
	More reference expression data
Orthologs
	79019
	66570
	ENSG00000100162
	ENSMUSG00000068101
	Q9NSP4
	Q9CQA0
NM_001002876; NM_001110215; NM_001304370; NM_001304371; NM_001304372;
	NM_001304373; NM_024053
	NM_001080158; NM_025639; NM_178269
NP_001002876; NP_001103685; NP_001291299; NP_001291300; NP_001291301;
	NP_001291302; NP_076958
	NP_001073627; NP_079915; NP_840000
	Wikidata
View/Edit Human	View/Edit Mouse

Centromere protein M also known as proliferation associated nuclear element 1 (PANE1) is a protein that in humans is encoded by the CENPM gene.^[5]^[6]^[7]

An alternative transcript of the CENPM gene encodes a leukocyte antigen that is selectively expressed in B-lymphoid cells.^[8]^[9] Centromere protein M is involved in centromere assembly and immune response.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100162 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000068101 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nature Cell Biology. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420. S2CID 26974412.
^ Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nature Cell Biology. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419. S2CID 205286556.
^ "Entrez Gene: CENPM centromere protein M".
^ Brickner AG, Evans AM, Mito JK, Xuereb SM, Feng X, Nishida T, Fairfull L, Ferrell RE, Foon KA, Hunt DF, Shabanowitz J, Engelhard VH, Riddell SR, Warren EH (2006). "The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL". Blood. 107 (9): 3779–86. doi:10.1182/blood-2005-08-3501. PMC 1895781. PMID 16391015.
^ Bierie B, Edwin M, Melenhorst JJ, Hennighausen L (July 2004). "The proliferation associated nuclear element (PANE1) is conserved between mammals and fish and preferentially expressed in activated lymphoid cells". Gene Expression Patterns. 4 (4): 389–95. doi:10.1016/j.modgep.2004.01.008. PMID 15183305.
^ Huang H, Deng H, Yang Y, Tang Z, Yang S, Mu Y, Cui W, Yuan J, Wu Z, Li K (2010). "Molecular characterization and association analysis of porcine PANE1 gene". Molecular Biology Reports. 37 (5): 2571–7. doi:10.1007/s11033-009-9775-0. PMID 19711193. S2CID 20345149.

External links

Human CENPM genome location and CENPM gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: Q9NSP4 (Human Centromere protein M (CENPM)) at the PDBe-KB.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100162 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000068101 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16622420-5] Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nature Cell Biology. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420. S2CID 26974412.

[pmid16622419-6] Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nature Cell Biology. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419. S2CID 205286556.

[entrez-7] "Entrez Gene: CENPM centromere protein M".

[pmid16391015-8] Brickner AG, Evans AM, Mito JK, Xuereb SM, Feng X, Nishida T, Fairfull L, Ferrell RE, Foon KA, Hunt DF, Shabanowitz J, Engelhard VH, Riddell SR, Warren EH (2006). "The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL". Blood. 107 (9): 3779–86. doi:10.1182/blood-2005-08-3501. PMC 1895781. PMID 16391015.

[9] Bierie B, Edwin M, Melenhorst JJ, Hennighausen L (July 2004). "The proliferation associated nuclear element (PANE1) is conserved between mammals and fish and preferentially expressed in activated lymphoid cells". Gene Expression Patterns. 4 (4): 389–95. doi:10.1016/j.modgep.2004.01.008. PMID 15183305.

[pmid19711193-10] Huang H, Deng H, Yang Y, Tang Z, Yang S, Mu Y, Cui W, Yuan J, Wu Z, Li K (2010). "Molecular characterization and association analysis of porcine PANE1 gene". Molecular Biology Reports. 37 (5): 2571–7. doi:10.1007/s11033-009-9775-0. PMID 19711193. S2CID 20345149.

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References

Further reading

External links