From Wikipedia, the free encyclopedia
Protein-coding gene in humans
Cdc42 effector protein 1 is a protein that in humans is encoded by the CDC42EP1 gene .[ 5] [ 6] [ 7]
CDC42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization. The protein encoded by this gene is a CDC42 binding protein that mediates actin cytoskeleton reorganization at the plasma membrane . The encoded protein, which is secreted, is primarily found in bone marrow . Two transcript variants encoding different isoforms have been found for this gene.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000128283 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049521 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Bahou WF, Campbell AD, Wicha MS (Aug 1992). "cDNA cloning and molecular characterization of MSE55, a novel human serum constituent protein that displays bone marrow stromal/endothelial cell-specific expression" . J Biol Chem . 267 (20): 13986–92. doi :10.1016/S0021-9258(19)49667-1 . PMID 1629197 .
^ Burbelo PD, Snow DM, Bahou W, Spiegel S (Sep 1999). "MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts" . Proc Natl Acad Sci U S A . 96 (16): 9083–8. Bibcode :1999PNAS...96.9083B . doi :10.1073/pnas.96.16.9083 . PMC 17736 . PMID 10430899 .
^ a b "Entrez Gene: CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1" .
Joberty G, Perlungher RR, Macara IG (2000). "The Borgs, a New Family of Cdc42 and TC10 GTPase-Interacting Proteins" . Mol. Cell. Biol . 19 (10): 6585–97. doi :10.1128/MCB.19.10.6585 . PMC 84628 . PMID 10490598 .
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22" . Nature . 402 (6761): 489–95. Bibcode :1999Natur.402..489D . doi :10.1038/990031 . PMID 10591208 .
Hirsch DS, Pirone DM, Burbelo PD (2001). "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes" . J. Biol. Chem . 276 (2): 875–83. doi :10.1074/jbc.M007039200 . PMID 11035016 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol . 21 (5): 566–9. doi :10.1038/nbt810 . PMID 12665801 . S2CID 23783563 .
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain" . Mol. Cell. Proteomics . 3 (11): 1093–101. doi :10.1074/mcp.M400085-MCP200 . PMID 15345747 .
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome" . Genome Biol . 5 (10): R84. doi :10.1186/gb-2004-5-10-r84 . PMC 545604 . PMID 15461802 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Zhang J, Zhu J, Bu X, et al. (2005). "Cdc42 and RhoB Activation Are Required for Mannose Receptor-mediated Phagocytosis by Human Alveolar Macrophages" . Mol. Biol. Cell . 16 (2): 824–34. doi :10.1091/mbc.E04-06-0463 . PMC 545914 . PMID 15574879 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 .
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 . PMID 16344560 .
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 . PMID 17081983 .