CD200R1

CD200R1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BFG, 4BFI
Identifiers
Aliases	CD200R1, CD200R, HCRTR2, MOX2R, OX2R, CD200 receptor 1
External IDs	OMIM: 607546; MGI: 1889024; HomoloGene: 10957; GeneCards: CD200R1; OMA:CD200R1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	112,975,103 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	44,615,341 bp
RNA expression pattern
	Top expressed in
	testicle; ; epithelium of nasopharynx; ; nasal epithelium; ; bone marrow cells; ; granulocyte; ; monocyte; ; lymph node; ; appendix; ; spleen; ; gallbladder;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; calvaria; ; pharynx; ; right lobe of liver; ; embryo; ; lumbar spinal ganglion; ; dermis; ; blood; ; spleen;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; immunoglobulin receptor activity; signaling receptor activity; glycosylated region protein binding;
Cellular component	integral component of membrane; extracellular region; receptor complex; membrane; external side of plasma membrane; plasma membrane; cell surface;
Biological process	viral process; regulation of immune response; signal transduction; heterotypic cell-cell adhesion; intracellular signal transduction; Fc receptor signaling pathway; regulation of neuroinflammatory response; negative regulation of neuroinflammatory response; negative regulation of neuron death; negative regulation of macrophage migration; negative regulation of T cell migration;
	Sources:Amigo / QuickGO
Orthologs
	131450
	57781
	ENSG00000163606
	ENSMUSG00000022667
	Q8TD46
	Q9ES57
	NM_138806; NM_138939; NM_138940; NM_170780
	NM_021325
	NP_620161; NP_620385; NP_620386; NP_740750
	NP_067300
	Wikidata
View/Edit Human	View/Edit Mouse

Cell surface transmembrane glycoprotein CD200 receptor 1 is a protein that in humans is encoded by the CD200R1 gene.^[5]^[6]^[7] CD200R1 is expressed on the surface of myeloid cells^[8] and CD4+ T cells.^[9] It interacts with CD200 transmembrane glycoprotein that can be expressed on variety of cells including neurons,^[10] epithelial cells,^[11] endothelial cells,^[12] fibroblasts,^[13] and lymphoid cells.^[14]

CD200R1 activation regulates the expression of pro-inflammatory molecules such as tumor necrosis factor (TNF-alpha),^[15] interferons, and inducible nitric oxide synthase (iNOS).^[16]

Function

This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163606 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022667 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, Brown MH, Barclay AN (August 2000). "Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function". Immunity. 13 (2): 233–42. doi:10.1016/S1074-7613(00)00023-6. PMID 10981966.
^ Dick AD, Broderick C, Forrester JV, Wright GJ (January 2001). "Distribution of OX2 antigen and OX2 receptor within retina". Investigative Ophthalmology & Visual Science. 42 (1): 170–6. PMID 11133863.
^ ^a ^b "Entrez Gene: CD200R1 CD200 receptor 1".
^ Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, Brown MH, Barclay AN (August 2000). "Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function". Immunity. 13 (2): 233–42. doi:10.1016/s1074-7613(00)00023-6. PMID 10981966.
^ Caserta S, Nausch N, Sawtell A, Drummond R, Barr T, Macdonald AS, Mutapi F, Zamoyska R (2012). "Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells". PLOS ONE. 7 (4): e35466. Bibcode:2012PLoSO...735466C. doi:10.1371/journal.pone.0035466. PMC 3322173. PMID 22496920.
^ Costello DA, Lyons A, Denieffe S, Browne TC, Cox FF, Lynch MA (October 2011). "Long term potentiation is impaired in membrane glycoprotein CD200-deficient mice: a role for Toll-like receptor activation". The Journal of Biological Chemistry. 286 (40): 34722–32. doi:10.1074/jbc.M111.280826. PMC 3186410. PMID 21835925.
^ Rosenblum MD, Olasz EB, Yancey KB, Woodliff JE, Lazarova Z, Gerber KA, Truitt RL (November 2004). "Expression of CD200 on epithelial cells of the murine hair follicle: a role in tissue-specific immune tolerance?". The Journal of Investigative Dermatology. 123 (5): 880–7. doi:10.1111/j.0022-202X.2004.23461.x. PMID 15482475.
^ Ko YC, Chien HF, Jiang-Shieh YF, Chang CY, Pai MH, Huang JP, Chen HM, Wu CH (January 2009). "Endothelial CD200 is heterogeneously distributed, regulated and involved in immune cell-endothelium interactions". Journal of Anatomy. 214 (1): 183–95. doi:10.1111/j.1469-7580.2008.00986.x. PMC 2667927. PMID 19166481.
^ Ishibashi M, Neri S, Hashimoto H, Miyashita T, Yoshida T, Nakamura Y, Udagawa H, Kirita K, Matsumoto S, Umemura S, Yoh K, Niho S, Tsuboi M, Masutomi K, Goto K, Ochiai A, Ishii G (April 2017). "CD200-positive cancer associated fibroblasts augment the sensitivity of Epidermal Growth Factor Receptor mutation-positive lung adenocarcinomas to EGFR Tyrosine kinase inhibitors". Scientific Reports. 7: 46662. Bibcode:2017NatSR...746662I. doi:10.1038/srep46662. PMC 5399371. PMID 28429795.
^ Gentry M, Bodo J, Durkin L, Hsi ED (February 2017). "Performance of a Commercially Available MAL Antibody in the Diagnosis of Primary Mediastinal Large B-Cell Lymphoma". The American Journal of Surgical Pathology. 41 (2): 189–194. doi:10.1097/PAS.0000000000000771. PMID 27879516. S2CID 25206581.
^ Pietilä M, Lehtonen S, Tuovinen E, Lähteenmäki K, Laitinen S, Leskelä HV, Nätynki A, Pesälä J, Nordström K, Lehenkari P (2012). "CD200 positive human mesenchymal stem cells suppress TNF-alpha secretion from CD200 receptor positive macrophage-like cells". PLOS ONE. 7 (2): e31671. Bibcode:2012PLoSO...731671P. doi:10.1371/journal.pone.0031671. PMC 3282758. PMID 22363701.
^ Carter DA, Dick AD (June 2004). "CD200 maintains microglial potential to migrate in adult human retinal explant model". Current Eye Research. 28 (6): 427–36. doi:10.1080/02713680490503778. PMID 15512951. S2CID 20846500.

External links

CD200R1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CD200R1 genome location and CD200R1 gene details page in the UCSC Genome Browser.
Human HCRTR2 genome location and HCRTR2 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163606 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022667 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10981966-5] Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, Brown MH, Barclay AN (August 2000). "Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function". Immunity. 13 (2): 233–42. doi:10.1016/S1074-7613(00)00023-6. PMID 10981966.

[pmid11133863-6] Dick AD, Broderick C, Forrester JV, Wright GJ (January 2001). "Distribution of OX2 antigen and OX2 receptor within retina". Investigative Ophthalmology & Visual Science. 42 (1): 170–6. PMID 11133863.

[entrez-7] "Entrez Gene: CD200R1 CD200 receptor 1".

[8] Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, Brown MH, Barclay AN (August 2000). "Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function". Immunity. 13 (2): 233–42. doi:10.1016/s1074-7613(00)00023-6. PMID 10981966.

[9] Caserta S, Nausch N, Sawtell A, Drummond R, Barr T, Macdonald AS, Mutapi F, Zamoyska R (2012). "Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells". PLOS ONE. 7 (4): e35466. Bibcode:2012PLoSO...735466C. doi:10.1371/journal.pone.0035466. PMC 3322173. PMID 22496920.

[10] Costello DA, Lyons A, Denieffe S, Browne TC, Cox FF, Lynch MA (October 2011). "Long term potentiation is impaired in membrane glycoprotein CD200-deficient mice: a role for Toll-like receptor activation". The Journal of Biological Chemistry. 286 (40): 34722–32. doi:10.1074/jbc.M111.280826. PMC 3186410. PMID 21835925.

[11] Rosenblum MD, Olasz EB, Yancey KB, Woodliff JE, Lazarova Z, Gerber KA, Truitt RL (November 2004). "Expression of CD200 on epithelial cells of the murine hair follicle: a role in tissue-specific immune tolerance?". The Journal of Investigative Dermatology. 123 (5): 880–7. doi:10.1111/j.0022-202X.2004.23461.x. PMID 15482475.

[12] Ko YC, Chien HF, Jiang-Shieh YF, Chang CY, Pai MH, Huang JP, Chen HM, Wu CH (January 2009). "Endothelial CD200 is heterogeneously distributed, regulated and involved in immune cell-endothelium interactions". Journal of Anatomy. 214 (1): 183–95. doi:10.1111/j.1469-7580.2008.00986.x. PMC 2667927. PMID 19166481.

[13] Ishibashi M, Neri S, Hashimoto H, Miyashita T, Yoshida T, Nakamura Y, Udagawa H, Kirita K, Matsumoto S, Umemura S, Yoh K, Niho S, Tsuboi M, Masutomi K, Goto K, Ochiai A, Ishii G (April 2017). "CD200-positive cancer associated fibroblasts augment the sensitivity of Epidermal Growth Factor Receptor mutation-positive lung adenocarcinomas to EGFR Tyrosine kinase inhibitors". Scientific Reports. 7: 46662. Bibcode:2017NatSR...746662I. doi:10.1038/srep46662. PMC 5399371. PMID 28429795.

[14] Gentry M, Bodo J, Durkin L, Hsi ED (February 2017). "Performance of a Commercially Available MAL Antibody in the Diagnosis of Primary Mediastinal Large B-Cell Lymphoma". The American Journal of Surgical Pathology. 41 (2): 189–194. doi:10.1097/PAS.0000000000000771. PMID 27879516. S2CID 25206581.

[15] Pietilä M, Lehtonen S, Tuovinen E, Lähteenmäki K, Laitinen S, Leskelä HV, Nätynki A, Pesälä J, Nordström K, Lehenkari P (2012). "CD200 positive human mesenchymal stem cells suppress TNF-alpha secretion from CD200 receptor positive macrophage-like cells". PLOS ONE. 7 (2): e31671. Bibcode:2012PLoSO...731671P. doi:10.1371/journal.pone.0031671. PMC 3282758. PMID 22363701.

[16] Carter DA, Dick AD (June 2004). "CD200 maintains microglial potential to migrate in adult human retinal explant model". Current Eye Research. 28 (6): 427–36. doi:10.1080/02713680490503778. PMID 15512951. S2CID 20846500.

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Function

References

Further reading

External links