CCT6B

CCT6B
Identifiers
Aliases	CCT6B, CCT-zeta-2, CCTZ-2, Cctz2, TCP-1-zeta-2, TSA303, chaperonin containing TCP1 subunit 6B
External IDs	OMIM: 610730; MGI: 1329013; HomoloGene: 55978; GeneCards: CCT6B; OMA:CCT6B - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	34,981,078 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	82,655,147 bp
RNA expression pattern
	Top expressed in
	sperm; ; left testis; ; right testis; ; testicle; ; gonad; ; olfactory zone of nasal mucosa; ; Achilles tendon; ; gastrocnemius muscle; ; palpebral conjunctiva; ; gastric mucosa;
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; blastocyst; ; embryo; ; Ileal epithelium; ; embryo; ; morula; ; morula; ; right kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ATP binding; protein folding chaperone activity; unfolded protein binding;
Cellular component	cytoplasm; cytosol; chaperonin-containing T-complex;
Biological process	toxin transport; protein folding; chaperone-mediated protein complex assembly; spermatogenesis; protein transport; 'de novo' protein folding; chaperone-mediated protein folding;
	Sources:Amigo / QuickGO
Orthologs
	10693
	12467
	ENSG00000132141
	ENSMUSG00000020698
	Q92526
	Q61390
	NM_001193529; NM_001193530; NM_006584
	NM_001291242; NM_009839
	NP_001180458; NP_001180459; NP_006575
	NP_001278171; NP_033969
	Wikidata
View/Edit Human	View/Edit Mouse

T-complex protein 1 subunit zeta-2 is a protein that in humans is encoded by the CCT6B gene.^[5]^[6]^[7]

This gene encodes a molecular chaperone that is a member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132141 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020698 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ozaki K, Kuroki T, Hayashi S, Nakamura Y (Jan 1997). "Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method". Genomics. 36 (2): 316–9. doi:10.1006/geno.1996.0467. PMID 8812458.
^ Kubota H, Hynes GM, Kerr SM, Willison KR (Feb 1997). "Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1" (PDF). FEBS Lett. 402 (1): 53–6. doi:10.1016/S0014-5793(96)01501-3. PMID 9013858. S2CID 1972107.
^ ^a ^b "Entrez Gene: CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)".

External links

Human CCT6B genome location and CCT6B gene details page in the UCSC Genome Browser.

Stirling PC, Cuéllar J, Alfaro GA, et al. (2006). "PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates". J. Biol. Chem. 281 (11): 7012–21. doi:10.1074/jbc.M513235200. PMID 16415341.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132141 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020698 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8812458-5] Ozaki K, Kuroki T, Hayashi S, Nakamura Y (Jan 1997). "Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method". Genomics. 36 (2): 316–9. doi:10.1006/geno.1996.0467. PMID 8812458.

[pmid9013858-6] Kubota H, Hynes GM, Kerr SM, Willison KR (Feb 1997). "Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1" (PDF). FEBS Lett. 402 (1): 53–6. doi:10.1016/S0014-5793(96)01501-3. PMID 9013858. S2CID 1972107.

[entrez-7] "Entrez Gene: CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)".

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References

External links

Further reading