CBX8

CBX8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3I91, 5EQ0, 2N4Q
Identifiers
Aliases	CBX8, PC3, RC1, chromobox 8
External IDs	OMIM: 617354; MGI: 1353589; HomoloGene: 32199; GeneCards: CBX8; OMA:CBX8 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	79,801,683 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	118,931,795 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; gonad; ; stromal cell of endometrium; ; right testis; ; ganglionic eminence; ; left testis; ; ventricular zone; ; apex of heart; ; granulocyte; ; right lobe of liver;
	Top expressed in
	granulocyte; ; respiratory epithelium; ; olfactory epithelium; ; Rostral migratory stream; ; neural layer of retina; ; thymus; ; proximal tubule; ; right kidney; ; yolk sac; ; ganglionic eminence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methylated histone binding; protein binding; single-stranded RNA binding; ubiquitin-protein transferase activator activity;
Cellular component	ubiquitin ligase complex; nucleoplasm; heterochromatin; PRC1 complex; PcG protein complex; nucleus;
Biological process	positive regulation of collagen biosynthetic process; regulation of transcription, DNA-templated; positive regulation of DNA repair; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of cell population proliferation; regulation of catalytic activity; histone ubiquitination; cellular response to hydrogen peroxide; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	57332
	30951
	ENSG00000141570
	ENSMUSG00000025578
	Q9HC52
	Q9QXV1
	NM_020649
	NM_013926
	NP_065700
	NP_038954
	Wikidata
View/Edit Human	View/Edit Mouse

Chromobox protein homolog 8 is a protein that in humans is encoded by the CBX8 gene.^[5]^[6]

Interactions

CBX8 has been shown to interact with RING1^[7] and MLLT1.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141570 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025578 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bardos JI, Saurin AJ, Tissot C, Duprez E, Freemont PS (Oct 2000). "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties". J Biol Chem. 275 (37): 28785–92. doi:10.1074/jbc.M001835200. PMID 10825164.
^ "Entrez Gene: CBX8 chromobox homolog 8 (Pc class homolog, Drosophila)".
^ Bárdos JI, Saurin A J, Tissot C, Duprez E, Freemont P S (Sep 2000). "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties". J. Biol. Chem. 275 (37): 28785–92. doi:10.1074/jbc.M001835200. ISSN 0021-9258. PMID 10825164.
^ García-Cuéllar MP, Zilles O, Schreiner S A, Birke M, Winkler T H, Slany R K (Jan 2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene. 20 (4): 411–9. doi:10.1038/sj.onc.1204108. ISSN 0950-9232. PMID 11313972.

External links

Human CBX8 genome location and CBX8 gene details page in the UCSC Genome Browser.

García-Cuéllar MP, Zilles O, Schreiner SA, et al. (2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene. 20 (4): 411–9. doi:10.1038/sj.onc.1204108. PMID 11313972.
Hemenway CS, de Erkenez AC, Gould GC (2001). "The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias". Oncogene. 20 (29): 3798–805. doi:10.1038/sj.onc.1204478. PMID 11439343. S2CID 25138105.
Levine SS, Weiss A, Erdjument-Bromage H, et al. (2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans". Mol. Cell. Biol. 22 (17): 6070–8. doi:10.1128/MCB.22.17.6070-6078.2002. PMC 134016. PMID 12167701.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.
Dietrich N, Bracken AP, Trinh E, et al. (2007). "Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus". EMBO J. 26 (6): 1637–48. doi:10.1038/sj.emboj.7601632. PMC 1829390. PMID 17332741.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141570 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025578 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10825164-5] Bardos JI, Saurin AJ, Tissot C, Duprez E, Freemont PS (Oct 2000). "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties". J Biol Chem. 275 (37): 28785–92. doi:10.1074/jbc.M001835200. PMID 10825164.

[entrez-6] "Entrez Gene: CBX8 chromobox homolog 8 (Pc class homolog, Drosophila)".

[autogenerated1-7] Bárdos JI, Saurin A J, Tissot C, Duprez E, Freemont P S (Sep 2000). "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties". J. Biol. Chem. 275 (37): 28785–92. doi:10.1074/jbc.M001835200. ISSN 0021-9258. PMID 10825164.

[pmid11313972-8] García-Cuéllar MP, Zilles O, Schreiner S A, Birke M, Winkler T H, Slany R K (Jan 2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene. 20 (4): 411–9. doi:10.1038/sj.onc.1204108. ISSN 0950-9232. PMID 11313972.

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Interactions

References

External links

Further reading