C3a receptor

C3AR1
Identifiers
Aliases	C3AR1, AZ3B, C3AR, HNFAG09, complement component 3a receptor 1, complement C3a receptor 1
External IDs	OMIM: 605246; MGI: 1097680; HomoloGene: 2992; GeneCards: C3AR1; OMA:C3AR1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	8,066,359 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	122,833,120 bp
RNA expression pattern
	Top expressed in
	monocyte; ; trabecular bone; ; decidua; ; amniotic fluid; ; bone marrow; ; blood; ; appendix; ; lower lobe of lung; ; bone marrow cells; ; superficial temporal artery;
	Top expressed in
	stroma of bone marrow; ; calvaria; ; ankle joint; ; ankle; ; lumbar subsegment of spinal cord; ; internal carotid artery; ; external carotid artery; ; sciatic nerve; ; white adipose tissue; ; carotid body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; complement receptor activity; complement component C3a receptor activity; G protein-coupled receptor activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; azurophil granule membrane; specific granule membrane;
Biological process	blood circulation; signal transduction; chemotaxis; positive regulation of neutrophil chemotaxis; positive regulation of angiogenesis; positive regulation of macrophage chemotaxis; inflammatory response; positive regulation of vascular endothelial growth factor production; G protein-coupled receptor signaling pathway; regulation of complement activation; phospholipase C-activating G protein-coupled receptor signaling pathway; neutrophil degranulation; leukocyte migration; cell chemotaxis; complement receptor mediated signaling pathway; positive regulation of cytosolic calcium ion concentration; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	719
	12267
	ENSG00000171860
	ENSMUSG00000040552
	Q16581
	O09047
	NM_004054; NM_001326475; NM_001326477
	NM_009779
	NP_001313404; NP_001313406; NP_004045
	NP_033909
	Wikidata
View/Edit Human	View/Edit Mouse

The C3a receptor also known as complement component 3a receptor 1 (C3AR1) is a G protein-coupled receptor protein involved in the complement system.^[5]^[6]

The receptor binds to complement component C3a, although there is limited evidence that this receptor also binds C4a in lesser mammals. This has yet to be proven true in humans.^[7] C3a receptor modulates immunity,^[8] arthritis, diet-induced obesity^[9] and cancers.^[10]

Agonists and antagonists

Potent and selective agonists^[11] and antagonists^[12] for C3aR have been discovered.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171860 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040552 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Roglic A, Prossnitz ER, Cavanagh SL, Pan Z, Zou A, Ye RD (February 1996). "cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1305 (1–2): 39–43. doi:10.1016/0167-4781(95)00209-x. PMID 8605247.
^ Ali H, Panettieri RA (February 2005). "Anaphylatoxin C3a receptors in asthma". Respiratory Research. 6 (1): 19. doi:10.1186/1465-9921-6-19. PMC 551592. PMID 15723703.
^ Klos A, Wende E, Wareham KJ, Monk PN (January 2013). "International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors". Pharmacological Reviews. 65 (1): 500–43. doi:10.1124/pr.111.005223. PMID 23383423.
^ Cravedi P, Leventhal J, Lakhani P, Ward SC, Donovan MJ, Heeger PS (October 2013). "Immune cell-derived C3a and C5a costimulate human T cell alloimmunity". American Journal of Transplantation. 13 (10): 2530–9. doi:10.1111/ajt.12405. PMC 3809075. PMID 24033923.
^ Lim J, Iyer A, Suen JY, Seow V, Reid RC, Brown L, Fairlie DP (February 2013). "C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling". FASEB Journal. 27 (2): 822–31. doi:10.1096/fj.12-220582. PMID 23118029. S2CID 25562647.
^ Sayegh ET, Bloch O, Parsa AT (August 2014). "Complement anaphylatoxins as immune regulators in cancer". Cancer Medicine. 3 (4): 747–58. doi:10.1002/cam4.241. PMC 4303144. PMID 24711204.
^ Reid RC, Yau MK, Singh R, Hamidon JK, Reed AN, Chu P, Suen JY, Stoermer MJ, Blakeney JS, Lim J, Faber JM, Fairlie DP (2013). "Downsizing a human inflammatory protein to a small molecule with equal potency and functionality". Nature Communications. 4: 2802. Bibcode:2013NatCo...4.2802R. doi:10.1038/ncomms3802. PMID 24257095.
^ Reid RC, Yau MK, Singh R, Lim J, Fairlie DP (August 2014). "Stereoelectronic effects dictate molecular conformation and biological function of heterocyclic amides". Journal of the American Chemical Society. 136 (34): 11914–7. doi:10.1021/ja506518t. PMID 25102224.

External links

"Anaphylatoxin Receptors: C3a". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2007-10-25.
C3AR1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human C3AR1 genome location and C3AR1 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171860 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040552 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8605247-5] Roglic A, Prossnitz ER, Cavanagh SL, Pan Z, Zou A, Ye RD (February 1996). "cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1305 (1–2): 39–43. doi:10.1016/0167-4781(95)00209-x. PMID 8605247.

[pmid15723703-6] Ali H, Panettieri RA (February 2005). "Anaphylatoxin C3a receptors in asthma". Respiratory Research. 6 (1): 19. doi:10.1186/1465-9921-6-19. PMC 551592. PMID 15723703.

[pmid=_23383423-7] Klos A, Wende E, Wareham KJ, Monk PN (January 2013). "International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors". Pharmacological Reviews. 65 (1): 500–43. doi:10.1124/pr.111.005223. PMID 23383423.

[8] Cravedi P, Leventhal J, Lakhani P, Ward SC, Donovan MJ, Heeger PS (October 2013). "Immune cell-derived C3a and C5a costimulate human T cell alloimmunity". American Journal of Transplantation. 13 (10): 2530–9. doi:10.1111/ajt.12405. PMC 3809075. PMID 24033923.

[9] Lim J, Iyer A, Suen JY, Seow V, Reid RC, Brown L, Fairlie DP (February 2013). "C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling". FASEB Journal. 27 (2): 822–31. doi:10.1096/fj.12-220582. PMID 23118029. S2CID 25562647.

[10] Sayegh ET, Bloch O, Parsa AT (August 2014). "Complement anaphylatoxins as immune regulators in cancer". Cancer Medicine. 3 (4): 747–58. doi:10.1002/cam4.241. PMC 4303144. PMID 24711204.

[11] Reid RC, Yau MK, Singh R, Hamidon JK, Reed AN, Chu P, Suen JY, Stoermer MJ, Blakeney JS, Lim J, Faber JM, Fairlie DP (2013). "Downsizing a human inflammatory protein to a small molecule with equal potency and functionality". Nature Communications. 4: 2802. Bibcode:2013NatCo...4.2802R. doi:10.1038/ncomms3802. PMID 24257095.

[12] Reid RC, Yau MK, Singh R, Lim J, Fairlie DP (August 2014). "Stereoelectronic effects dictate molecular conformation and biological function of heterocyclic amides". Journal of the American Chemical Society. 136 (34): 11914–7. doi:10.1021/ja506518t. PMID 25102224.

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Agonists and antagonists

References

Further reading

External links