Sulmazole

Sulmazole
Identifiers
	IUPAC name 2-(2-Methoxy-4-methylsulfinylphenyl)-1H-imidazo[4,5-b]pyridine;
CAS Number	73384-60-8;
PubChem CID	5353;
UNII	HK56EH9K44;
CompTox Dashboard (EPA)	DTXSID1040617 ;
ECHA InfoCard	100.070.348
Chemical and physical data
Formula	C14H13N3O2S
Molar mass	287.34 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC1=C(C=CC(=C1)S(=O)C)C2=NC3=C(N2)C=CC=N3;

Sulmazole is a cardiotonic drug.^[1] Sulmazole has the chemical formula C₁₄H₁₃N₃O₂S^[2] and a molecular weight of 287.34 g/mol.^[2]

Sulmazole has been shown to improve cardiac index and reduce pulmonary capillary wedge pressure without significant changes in a person's heart rate or arterial pressure.^[3] Sulmazole inhibits the A1 adenosine receptor and functionally blocks Gi, an inhibitory regulator.^[1] Sulmazole is also a phosphodiesterase inhibitor.^[3] Sulmazole is classified as an imidazopyridine and a sulfoxide.^[2] Sulmazole can be taken intravenously or orally.^[3] Side effects from sulmazole include blurring vision and temporary color blindness.^[3]

References

^ ^a ^b Parsons WJ, Ramkumar V, Stiles GL (April 1988). "The new cardiotonic agent sulmazole is an A1 adenosine receptor antagonist and functionally blocks the inhibitory regulator, Gi". Molecular Pharmacology. 33 (4): 441–8. PMID 3128727.
^ ^a ^b ^c PubChem. "Sulmazole". pubchem.ncbi.nlm.nih.gov. Retrieved 2019-09-30.
^ ^a ^b ^c ^d "NCATS Inxight: Drugs — SULMAZOLE". drugs.ncats.io. Retrieved 2019-09-30.