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Protein-coding gene in the species Homo sapiens
Beta-1,4-galactosyltransferase 2 is an enzyme that in humans is encoded by the B4GALT2 gene .[ 5] [ 6] [ 7]
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose ; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc , Glc , and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins , they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity , the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene synthesizes N-acetyllactosamine in glycolipids and glycoproteins . Its substrate specificity is affected by alpha-lactalbumin but it is not expressed in lactating mammary tissue . Two transcript variants encoding the same protein have been found for this gene.[ 7]
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