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Androgen synthesis inhibitor

From Wikipedia, the free encyclopedia

An androgen synthesis inhibitor is a type of drug which inhibits the enzymatic synthesis of androgens, such as testosterone and dihydrotestosterone (DHT).[1] They include:

Inhibitors of cholesterol synthesis can also reduce androgen production by inhibiting cholesterol production.

Androgen synthesis inhibitors have medical applications in the treatment of benign prostatic hypertrophy, prostate cancer,[1] androgenetic alopecia, hirsutism, precocious puberty, and hyperandrogenism, among other androgen-dependent conditions.

Because androgens are the endogenous precursors of estrogens, androgen synthesis inhibitors also function as estrogen synthesis inhibitors and can reduce estrogen production and levels.

See also

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References

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  1. ^ a b c Stein MN, Patel N, Bershadskiy A, Sokoloff A, Singer EA (2014). "Androgen synthesis inhibitors in the treatment of castration-resistant prostate cancer". Asian J Androl. 16 (3): 387–400. doi:10.4103/1008-682X.129133. PMC 4023364. PMID 24759590.