AZI2

AZI2
Identifiers
Aliases	AZI2, AZ2, NAP1, TILP, 5-azacytidine induced 2
External IDs	OMIM: 609916; MGI: 1351332; HomoloGene: 8443; GeneCards: AZI2; OMA:AZI2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	28,349,050 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	118,069,794 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; monocyte; ; mucosa of paranasal sinus; ; Achilles tendon; ; buccal mucosa cell; ; gastric mucosa; ; right lung; ; lower lobe of lung; ; ganglionic eminence; ; ventricular zone;
	Top expressed in
	neural layer of retina; ; spermatid; ; genital tubercle; ; tail of embryo; ; spermatocyte; ; ventricular zone; ; dentate gyrus of hippocampal formation granule cell; ; parotid gland; ; atrioventricular valve; ; seminal vesicula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm;
Biological process	interleukin-6 production; dendritic cell differentiation; cytokine production; tumor necrosis factor production; interferon-alpha production; I-kappaB kinase/NF-kappaB signaling; T cell activation; dendritic cell proliferation; mitotic cell cycle; viral process;
	Sources:Amigo / QuickGO
Orthologs
	64343
	27215
	ENSG00000163512
	ENSMUSG00000039285
	Q9H6S1
	Q9QYP6
	NM_001134432; NM_001134433; NM_001271650; NM_022461; NM_203326
	NM_001048146; NM_001286507; NM_001286508; NM_013727
	NP_001127904; NP_001127905; NP_001258579; NP_071906
	NP_001041611; NP_001273436; NP_001273437; NP_038755
	Wikidata
View/Edit Human	View/Edit Mouse

5-azacytidine-induced protein 2 is a protein that in humans is encoded by the AZI2 gene.^[5]^[6]

AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003).[supplied by OMIM]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163512 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039285 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Miyagawa J, Muguruma M, Aoto H, Suetake I, Nakamura M, Tajima S (Jan 2000). "Isolation of the novel cDNA of a gene of which expression is induced by a demethylating stimulus". Gene. 240 (2): 289–95. doi:10.1016/S0378-1119(99)00450-3. PMID 10580148.
^ ^a ^b "Entrez Gene: AZI2 5-azacytidine induced 2".

External links

Human AZI2 genome location and AZI2 gene details page in the UCSC Genome Browser.

Funami K, Sasai M, Ohba Y, Oshiumi H, Seya T, Matsumoto M (2007). "Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA". J. Immunol. 179 (10): 6867–72. doi:10.4049/jimmunol.179.10.6867. PMID 17982077.
Sasai M, Shingai M, Funami K, Yoneyama M, Fujita T, Matsumoto M, et al. (2007). "NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction". J. Immunol. 177 (12): 8676–83. doi:10.4049/jimmunol.177.12.8676. PMID 17142768.
Sasai M, Oshiumi H, Matsumoto M, Inoue N, Fujita F, Nakanishi M, et al. (2005). "Cutting Edge: NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation". J. Immunol. 174 (1): 27–30. doi:10.4049/jimmunol.174.1.27. PMID 15611223.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Fujita F, Taniguchi Y, Kato T, Narita Y, Furuya A, Ogawa T, et al. (2003). "Identification of NAP1, a Regulatory Subunit of IκB Kinase-Related Kinases That Potentiates NF-κB Signaling". Mol. Cell. Biol. 23 (21): 7780–93. doi:10.1128/MCB.23.21.7780-7793.2003. PMC 207563. PMID 14560022.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163512 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039285 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10580148-5] Miyagawa J, Muguruma M, Aoto H, Suetake I, Nakamura M, Tajima S (Jan 2000). "Isolation of the novel cDNA of a gene of which expression is induced by a demethylating stimulus". Gene. 240 (2): 289–95. doi:10.1016/S0378-1119(99)00450-3. PMID 10580148.

[entrez-6] "Entrez Gene: AZI2 5-azacytidine induced 2".

[1]

[2]

[3]

[4]

[5]

[6]

References

External links

Further reading