AGPAT1

AGPAT1
Identifiers
Aliases	AGPAT1, 1-G15, LPAAT-alpha, LPAATA, 1-acylglycerol-3-phosphate O-acyltransferase 1
External IDs	OMIM: 603099; MGI: 1932075; HomoloGene: 55973; GeneCards: AGPAT1; OMA:AGPAT1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.32 Start 32,168,212 bp End 32,178,096 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 B1|17 18.18 cM Start 34,823,236 bp End 34,832,423 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe superior frontal gyrus left testis right testis anterior cingulate cortex primary visual cortex stromal cell of endometrium hippocampus proper dorsolateral prefrontal cortex nucleus accumbens Top expressed in spermatid spermatocyte endocardial cushion muscle of thigh superior frontal gyrus yolk sac primary visual cortex atrioventricular valve dentate gyrus of hippocampal formation granule cell granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity acyltransferase activity 1-acylglycerol-3-phosphate O-acyltransferase activity protein binding Cellular component integral component of membrane endoplasmic reticulum membrane membrane endoplasmic reticulum Biological process phosphatidic acid biosynthetic process CDP-diacylglycerol biosynthetic process positive regulation of cytokine-mediated signaling pathway positive regulation of cytokine production lipid metabolism phospholipid biosynthetic process phospholipid metabolic process metabolism positive regulation of cellular metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10554 55979 Ensembl ENSG00000236873 ENSG00000235758 ENSG00000228892 ENSG00000204310 ENSG00000226467 ENSG00000227642 ENSG00000206324 ENSMUSG00000034254 UniProt Q99943 O35083 RefSeq (mRNA) NM_006411 NM_032741 NM_001371437 NM_001371438 NM_001371439 NM_001163379 NM_018862 RefSeq (protein) NP_006402 NP_116130 NP_001358366 NP_001358367 NP_001358368 NP_001156851 NP_061350 Location (UCSC) Chr 6: 32.17 – 32.18 Mb Chr 17: 34.82 – 34.83 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

1-acyl-sn-glycerol-3-phosphate acyltransferase alpha is an enzyme that in humans is encoded by the AGPAT1 gene.

This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein.

External links

• Human AGPAT1 genome location and AGPAT1 gene details page in the UCSC Genome Browser.

Further reading

• Leung DW (2001). "The structure and functions of human lysophosphatidic acid acyltransferases". Front. Biosci. 6 (1): D944–53. doi:10.2741/Leung. PMID 11487472.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• West J, Tompkins CK, Balantac N, et al. (1997). "Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells". DNA Cell Biol. 16 (6): 691–701. doi:10.1089/dna.1997.16.691. PMID 9212163.
• Aguado B, Campbell RD (1998). "Human lysophosphatidic acid acyltransferase is encoded by a gene located in the major histocompatibility complex". Biochem. Soc. Trans. 25 (4): S597. doi:10.1042/bst025s597. PMID 9450025.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Servillo L, Balestrieri C, Giovane A, et al. (2006). "Lysophospholipid transacetylase in the regulation of PAF levels in human monocytes and macrophages". FASEB J. 20 (7): 1015–7. doi:10.1096/fj.05-5059fje. PMID 16571775. S2CID 24392328.
• Lloyd EE, Gaubatz JW, Burns AR, Pownall HJ (2007). "Sustained elevations in NEFA induce cyclooxygenase-2 activity and potentiate THP-1 macrophage foam cell formation". Atherosclerosis. 192 (1): 49–55. doi:10.1016/j.atherosclerosis.2006.06.014. PMID 16870193.