The season began with much optimism, with the Lions hoping to improve on their 9–7 record from 2000; however, the Lions were extremely disappointing and had the worst start to an NFL season since the 1986 Indianapolis Colts began 0–13. They were widely believed to be likely to suffer the NFL’s first 0–16 season[3] before they defeated the Minnesota Vikings. Prior to that, they had lost an NFL record nine consecutive games by eight points or less.[3]
This was the final season that the Lions played at the Pontiac Silverdome before moving to Ford Field the following season, as well as the final season for the NFC Central Division, which would dissolve following the NFL's realignment in 2002, although all NFC Central teams except the Tampa Bay Buccaneers formed the new NFC North Division.
The Lions closed the Silverdome by defeating the Dallas Cowboys 15–10 in the regular season finale. Coincidentally, the Cowboys defeated the Lions 36–10 in the first regular season game at the Silverdome (then known as Pontiac Metropolitan Stadium) in 1975.
This would also be the first season under new general manager Matt Millen, as he would be the team's general manager for the next six seasons and first 3 games of the 2008 season. This would start a stage of futility for the Lions, as they would fail to post a winning record with Millen as general manager.
Quarterback Ty Detmer made his first start for the Lions, ending the game with seven interceptions. Despite this, the Lions' defense kept the game somewhat close, picking off Cleveland quarterback Tim Couch twice, including a 26-yard pick six by cornerback Terry Fair.
^ abThe Lions were originally scheduled to host the Dallas Cowboys during Week 2 of the original NFL schedule (September 16) at Pontiac Silverdome. However, due to the September 11 attacks, the game was rescheduled to Week 17.