Phosphatidylinositol 4-phosphate

Phosphatidylinositol-4-phosphate (PtdIns4P, PI-4-P, PI4P, or PIP) is a precursor of phosphatidylinositol (4,5)-bisphosphate. PtdIns4P is prevalent in the membrane of the Golgi apparatus.

In the Golgi apparatus, PtdIns4P binds to the GTP-binding protein ARF and to effector proteins, including four-phosphate-adaptor protein 1 and 2 (PLEKHA3 and PLEKHA8).^[1] This three molecule complex recruits proteins that need to be carried to the cell membrane.^[2]

There is now evidence that PI-4-P is capable of deforming lipid systems into tightly curved assemblies,^[3]^[4] this is consistent with similar behaviour observed in phosphatidylinositol.

References

^ Godi, Anna; Campli, Antonella Di; Konstantakopoulos, Athanasios; Tullio, Giuseppe Di; Alessi, Dario R.; Kular, Gursant S.; Daniele, Tiziana; Marra, Pierfrancesco; Lucocq, John M.; Matteis, M. Antonietta De (2004-05-01). "FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P". Nature Cell Biology. 6 (5): 393–404. doi:10.1038/ncb1119. ISSN 1465-7392. PMID 15107860. S2CID 25874412.
^ Choudhury, Rawshan R.; Hyvola, Noora; Lowe, Martin (2005-01-01). "Phosphoinositides and membrane traffic at the trans-Golgi network". Biochemical Society Symposia. 72 (72): 31–38. doi:10.1042/bss0720031. ISSN 0067-8694. PMID 15649127.
^ Furse, Samuel; Brooks, Nicholas J.; Seddon, Annela M.; Woscholski, Rüdiger; Templer, Richard H.; Gaffney, Piers R. J.; Ces, Oscar (2012). "Lipid Membrane Curvature Induced by Distearoyl Phosphatidylinositol 4-Phosphate". Soft Matter. 8 (11): 3090–3093. Bibcode:2012SMat....8.3090F. doi:10.1039/c2sm07358g.
^ Furse, Samuel; Brooks, Nicholas J.; Woscholski, Rüdiger; Gaffney, Piers R. J.; Templer, Richard H. (2016). "Pressure-dependent inverse bicontinuous cubic phase formation in a phosphatidylinositol 4-phosphate/phosphatidylcholine system". Chemical Data Collections. 3–4: 15–20. doi:10.1016/j.cdc.2016.08.001. hdl:10044/1/42515.

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[1] Godi, Anna; Campli, Antonella Di; Konstantakopoulos, Athanasios; Tullio, Giuseppe Di; Alessi, Dario R.; Kular, Gursant S.; Daniele, Tiziana; Marra, Pierfrancesco; Lucocq, John M.; Matteis, M. Antonietta De (2004-05-01). "FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P". Nature Cell Biology. 6 (5): 393–404. doi:10.1038/ncb1119. ISSN 1465-7392. PMID 15107860. S2CID 25874412.

[2] Choudhury, Rawshan R.; Hyvola, Noora; Lowe, Martin (2005-01-01). "Phosphoinositides and membrane traffic at the trans-Golgi network". Biochemical Society Symposia. 72 (72): 31–38. doi:10.1042/bss0720031. ISSN 0067-8694. PMID 15649127.

[3] Furse, Samuel; Brooks, Nicholas J.; Seddon, Annela M.; Woscholski, Rüdiger; Templer, Richard H.; Gaffney, Piers R. J.; Ces, Oscar (2012). "Lipid Membrane Curvature Induced by Distearoyl Phosphatidylinositol 4-Phosphate". Soft Matter. 8 (11): 3090–3093. Bibcode:2012SMat....8.3090F. doi:10.1039/c2sm07358g.

[4] Furse, Samuel; Brooks, Nicholas J.; Woscholski, Rüdiger; Gaffney, Piers R. J.; Templer, Richard H. (2016). "Pressure-dependent inverse bicontinuous cubic phase formation in a phosphatidylinositol 4-phosphate/phosphatidylcholine system". Chemical Data Collections. 3–4: 15–20. doi:10.1016/j.cdc.2016.08.001. hdl:10044/1/42515.

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See also

References